Lymphoid enhancer-binding factor 1

LEF1

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
2LEF, 3OUW, 3OUX

Identifiers

Aliases

LEF1, LEF-1, TCF10, TCF1ALPHA, TCF7L3, lymphoid enhancer binding factor 1

External IDs

MGI: 96770 HomoloGene: 7813 GeneCards: LEF1

Genetically Related Diseases

chronic lymphocytic leukemia, systemic lupus erythematosus

Gene ontology
Molecular function	• transcription factor activity, sequence-specific DNA binding • transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding • histone deacetylase binding • enhancer binding • armadillo repeat domain binding • transcription regulatory region DNA binding • estrogen receptor binding • RNA polymerase II regulatory region sequence-specific DNA binding • transcription factor binding • estrogen receptor activity • RNA polymerase II core promoter proximal region sequence-specific DNA binding • gamma-catenin binding • histone binding • C2H2 zinc finger domain binding • chromatin binding • cysteine-type endopeptidase inhibitor activity involved in apoptotic process • protein binding • DNA binding, bending • DNA binding • sequence-specific DNA binding • transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding • transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding • beta-catenin binding
Cellular component	• cytoplasm • nucleus • transcription factor complex • beta-catenin-TCF complex • nucleoplasm • protein-DNA complex
Biological process	• somitogenesis • tongue development • paraxial mesoderm formation • regulation of transcription from RNA polymerase II promoter • negative regulation of DNA binding • T cell receptor V(D)J recombination • transcription from RNA polymerase II promoter • cellular response to cytokine stimulus • mammary gland development • negative regulation of interleukin-13 production • odontogenesis of dentin-containing tooth • muscle fiber development • apoptotic process involved in blood vessel morphogenesis • cell chemotaxis • negative regulation of canonical Wnt signaling pathway • face morphogenesis • neutrophil differentiation • negative regulation of interleukin-5 production • regulation of transcription, DNA-templated • dentate gyrus development • apoptotic process involved in morphogenesis • transcription, DNA-templated • positive regulation of transcription, DNA-templated • positive regulation of cell growth • regulation of Wnt signaling pathway • embryonic limb morphogenesis • hypothalamus development • branching involved in blood vessel morphogenesis • trachea gland development • regulation of striated muscle tissue development • palate development • positive regulation of cell-cell adhesion • forebrain neuroblast division • eye pigmentation • negative regulation of apoptotic process • sprouting angiogenesis • negative regulation of transcription from RNA polymerase II promoter • positive regulation of epithelial to mesenchymal transition • BMP signaling pathway • positive regulation of cell cycle process • osteoblast differentiation • histone H3 acetylation • formation of radial glial scaffolds • positive regulation of granulocyte differentiation • alpha-beta T cell differentiation • canonical Wnt signaling pathway • negative regulation of transcription, DNA-templated • positive regulation by host of viral transcription • sensory perception of taste • cellular response to interleukin-4 • negative regulation of cysteine-type endopeptidase activity involved in apoptotic process • cell development • negative regulation of cell-cell adhesion • negative regulation of interleukin-4 production • negative regulation of striated muscle tissue development • positive regulation of cell migration • Wnt signaling pathway • T-helper 1 cell differentiation • positive regulation of cell proliferation in bone marrow • anatomical structure regression • chorio-allantoic fusion • negative regulation of apoptotic process in bone marrow • B cell proliferation • positive regulation of gene expression • vasculature development • forebrain radial glial cell differentiation • neural crest cell migration • positive regulation of cell proliferation • forebrain neuron differentiation • histone H4 acetylation • hippocampus development • negative regulation of estrogen receptor binding • positive regulation of transcription from RNA polymerase II promoter • Wnt signaling pathway, calcium modulating pathway • steroid hormone mediated signaling pathway • odontoblast differentiation • beta-catenin-TCF complex assembly • epithelial to mesenchymal transition • regulation of cell-cell adhesion
Sources:Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

Entrez


51176


16842

Ensembl


ENSG00000138795


ENSMUSG00000027985

UniProt


Q9UJU2


P27782

RefSeq (mRNA)


NM_001130713 NM_001130714 NM_001166119 NM_016269


NM_001276402 NM_001276403 NM_010703

RefSeq (protein)


NP_001124185 NP_001124186 NP_001159591 NP_057353 NP_057353.1


NP_034833.2 NP_001263331 NP_001263332 NP_034833

Location (UCSC)

Chr 4: 108.05 – 108.17 Mb

Chr 3: 131.11 – 131.22 Mb

PubMed search

2LEF, 3OUW, 3OUX

NM_001130713
NM_001130714
NM_001166119
NM_016269

NM_001276402
NM_001276403
NM_010703

NP_001124185
NP_001124186
NP_001159591
NP_057353
NP_057353.1

...
Wikipedia