MCP-1

CCL2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1DOK, 1DOL, 1DOM, 1DON, 1ML0, 2BDN, 2NZ1, 4DN4, 3IFD, 4R8I, 4ZK9
Identifiers
Aliases	CCL2, GDCF-2, HC11, HSMCR30, MCAF, MCP-1, MCP1, SCYA2, SMC-CF, C-C motif chemokine ligand 2
External IDs	OMIM: 158105 MGI: 108224 HomoloGene: 2245 GeneCards: CCL2
Gene ontology Molecular function • receptor binding • protein kinase activity • cytokine activity • protein binding • chemokine activity • CCR2 chemokine receptor binding Cellular component • extracellular region • extracellular space • intracellular • cell Biological process • negative regulation of neuron apoptotic process • viral genome replication • negative regulation of natural killer cell chemotaxis • protein phosphorylation • cell surface receptor signaling pathway • humoral immune response • angiogenesis • positive regulation of ERK1 and ERK2 cascade • animal organ morphogenesis • cellular homeostasis • cellular response to fibroblast growth factor stimulus • positive regulation of GTPase activity • inflammatory response • G-protein coupled receptor signaling pathway • monocyte chemotaxis • G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger • cellular response to organic cyclic compound • chemotaxis • cell adhesion • immune response • regulation of cell shape • lipopolysaccharide-mediated signaling pathway • JAK-STAT cascade • response to bacterium • protein kinase B signaling • astrocyte cell migration • negative regulation of glial cell apoptotic process • PERK-mediated unfolded protein response • MAPK cascade • positive regulation of calcium ion import • cytoskeleton organization • signal transduction • cytokine-mediated signaling pathway • neutrophil chemotaxis • helper T cell extravasation • macrophage chemotaxis • positive regulation of T cell activation • positive regulation of nitric-oxide synthase biosynthetic process • chemokine-mediated signaling pathway • cellular response to lipopolysaccharide • cellular response to interferon-gamma • cellular response to interleukin-1 • cellular response to tumor necrosis factor • positive regulation of apoptotic cell clearance Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	6347	20293
Ensembl	ENSG00000108691	ENSMUSG00000035352
UniProt	P13500	Q62401
RefSeq (mRNA)	NM_002982	NM_011331
RefSeq (protein)	NP_002973	NP_035461
Location (UCSC)	Chr 17: 34.26 – 34.26 Mb	Chr 11: 82.1 – 82.1 Mb
PubMed search

For the ICAO airport code see Candle Lake Airpark, for the diradical compound see Dichlorocarbene.

1DOK, 1DOL, 1DOM, 1DON, 1ML0, 2BDN, 2NZ1, 4DN4, 3IFD, 4R8I, 4ZK9

6347

20293

ENSG00000108691

ENSMUSG00000035352

P13500

Q62401

NM_002982

NM_011331

NP_002973

...
Wikipedia