MEST (gene)

MEST
Identifiers
Aliases	MEST, PEG1, mesoderm specific transcript
External IDs	MGI: 96968 HomoloGene: 1800 GeneCards: MEST
Gene location (Human) Chr. Chromosome 7 (human) Band No data available Start 130,486,171 bp End 130,506,296 bp
Gene location (Mouse) Chr. Chromosome 6 (mouse) Band No data available Start 30,723,547 bp End 30,748,465 bp
RNA expression pattern More reference expression data
Gene ontology Molecular function • catalytic activity • hydrolase activity Cellular component • integral component of membrane • extracellular exosome • endoplasmic reticulum membrane • endoplasmic reticulum • membrane Biological process • mesoderm development Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	4232	17294
Ensembl	ENSG00000106484	ENSMUSG00000051855
UniProt	Q5EB52	Q07646
RefSeq (mRNA)	NM_001253900 NM_001253901 NM_001253902 NM_002402 NM_177524 NM_177525	NM_001252292 NM_001252293 NM_008590
RefSeq (protein)	NP_001240829 NP_001240830 NP_001240831 NP_002393 NP_803490 NP_803491	NP_001239221 NP_001239222 NP_032616
Location (UCSC)	Chr 7: 130.49 – 130.51 Mb	Chr 7: 30.72 – 30.75 Mb
PubMed search

4232

17294

ENSG00000106484

ENSMUSG00000051855

Q5EB52

Q07646

NM_177525

NM_001252292
NM_001252293
NM_008590

NP_803491

NP_001239221
NP_001239222
NP_032616

Mesoderm-specific transcript homolog protein is a protein that in humans is encoded by the MEST gene.

This gene encodes a member of the [alpha]/[beta] hydrolase fold family and has isoform-specific imprinting. The loss of imprinting of this gene has been linked to certain types of cancer and may be due to promotor switching. The encoded protein may play a role in development. Three transcript variants encoding two distinct isoforms have been identified for this gene. A pseudogene for this locus is located on chromosome 6.

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