MEX3D

MEX3D
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2DGR
Identifiers
Aliases	MEX3D, MEX-3D, MEX3, OK/SW-cl.4, RKHD1, RNF193, TINO, mex-3 RNA binding family member D
External IDs	MGI: 2681847 HomoloGene: 16890 GeneCards: MEX3D
Gene ontology Molecular function • zinc ion binding • AU-rich element binding • metal ion binding • nucleic acid binding • RNA binding Cellular component • cytoplasm • perinuclear region of cytoplasm • nucleus Biological process • mRNA destabilization • mRNA localization resulting in posttranscriptional regulation of gene expression Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	399664	237400
Ensembl	ENSG00000181588	ENSMUSG00000048696
UniProt	Q86XN8	Q3UE17
RefSeq (mRNA)	NM_001174118 NM_203304	NM_198615
RefSeq (protein)	NP_001167589 NP_976049	NP_941017.2 NP_941017
Location (UCSC)	Chr 19: 1.55 – 1.57 Mb	Chr 10: 80.38 – 80.39 Mb
PubMed search

2DGR

399664

237400

ENSG00000181588

ENSMUSG00000048696

Q86XN8

Q3UE17

NM_001174118
NM_203304

NM_198615

NP_001167589
NP_976049

NP_941017.2
NP_941017

Mex-3 homolog D (C. elegans), also known as MEX3D, is a protein that in humans is encoded by the MEX3D gene.

MEX3D is an RNA binding protein that interacts with AU-rich elements of Bcl-2. Upon binding, MEX3D has a negative regulatory action on Bcl-2 expression at the posttranscriptional level.

MEX3 proteins contain two N-terminal heterogeneous nuclear ribonucleoprotein K homology motifs ( KH domain ) and a RING domain at the C-terminus.

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