MICB

MICB
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 1JE6, 2WY3
Identifiers
Aliases	MICB, PERB11.2, MHC class I polypeptide-related sequence B
External IDs	MGI: 2179989 HomoloGene: 88329 GeneCards: MICB
Gene ontology Molecular function • natural killer cell lectin-like receptor binding Cellular component • integral component of membrane • cell surface • plasma membrane • membrane Biological process • immune system process • gamma-delta T cell activation • negative regulation of defense response to virus by host • viral process • response to heat • cytolysis • adaptive immune response • response to oxidative stress • response to retinoic acid • T cell mediated cytotoxicity • natural killer cell mediated cytotoxicity • regulation of immune response • immune response-activating cell surface receptor signaling pathway Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	4277	243864
Ensembl	ENSG00000231179 ENSG00000224378 ENSG00000206449 ENSG00000227772 ENSG00000238289 ENSG00000231372 ENSG00000234218 ENSG00000204516	ENSMUSG00000040987
UniProt	Q29980	n/a
RefSeq (mRNA)	NM_001289160 NM_001289161 NM_005931	NM_153760 NM_153761
RefSeq (protein)	NP_001276089 NP_001276090 NP_005922	n/a
Location (UCSC)	Chr 6: 31.49 – 31.51 Mb	Chr 7: 18.84 – 18.86 Mb
PubMed search

1JE6, 2WY3

4277

243864

ENSG00000231372
ENSG00000234218
ENSG00000204516

ENSMUSG00000040987

Q29980

n/a

NM_001289160
NM_001289161
NM_005931

NM_153760
NM_153761

NP_001276089
NP_001276090
NP_005922

n/a

MHC class I polypeptide-related sequence B (MICB) is a protein that is encoded by the MICB gene located within MHC locus. MICB is related to MHC class I and has similar domain structure, which is made up of external α1α2α3 domain, transmembrane segment and C-terminal cytoplasmic tail. MICB is a stress-induced ligand for NKG2D receptor. The heat shock stress pathway is involved in the regulation of MICB expression as transcription of MICB is regulated by promoter heat shock element.

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Wikipedia