MID2

MID2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2DJA, 2DMK
Identifiers
Aliases	MID2, FXY2, MRX101, RNF60, TRIM1, midline 2
External IDs	MGI: 1344333 HomoloGene: 8028 GeneCards: MID2
Gene location (Human) Chr. X chromosome (human) Band Xq22.3 Start 107,825,755 bp End 107,927,193 bp
Gene location (Mouse) Chr. X chromosome (mouse) Band X F1|X 61.35 cM Start 140,664,599 bp End 140,767,715 bp
RNA expression pattern More reference expression data
Gene ontology Molecular function • protein homodimerization activity • microtubule binding • zinc ion binding • metal ion binding • phosphoprotein binding • protein binding • protein heterodimerization activity • identical protein binding • transferase activity Cellular component • cytoplasm • intracellular • microtubule • extracellular exosome • cytoskeleton Biological process • positive regulation of autophagy • positive regulation of sequence-specific DNA binding transcription factor activity • protein localization to microtubule • positive regulation of NF-kappaB transcription factor activity • protein ubiquitination • positive regulation of I-kappaB kinase/NF-kappaB signaling • innate immune response Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	11043	23947
Ensembl	ENSG00000080561	ENSMUSG00000000266
UniProt	Q9UJV3	Q9QUS6
RefSeq (mRNA)	NM_012216 NM_052817	NM_011845
RefSeq (protein)	NP_036348 NP_438112	NP_035975
Location (UCSC)	Chr X: 107.83 – 107.93 Mb	Chr X: 140.66 – 140.77 Mb
PubMed search

2DJA, 2DMK

11043

23947

ENSG00000080561

ENSMUSG00000000266

Q9UJV3

Q9QUS6

NM_012216
NM_052817

NM_011845

NP_036348
NP_438112

NP_035975

Midline-2 is a protein that in humans is encoded by the MID2 gene.

The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to microtubular structures in the cytoplasm. Its function has not been identified. Alternate splicing of this gene results in two transcript variants encoding different isoforms.

MID2 has been shown to interact with MID1.

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