MIP-3 alpha

CCL20
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2JYO, 1M8A, 2HCI
Identifiers
Aliases	CCL20, CKb4, Exodus, LARC, MIP-3-alpha, MIP-3a, MIP3A, SCYA20, ST38, chemokine (C-C motif) ligand 20, C-C motif chemokine ligand 20
External IDs	OMIM: 601960 MGI: 1329031 HomoloGene: 3375 GeneCards: CCL20
Gene location (Human) Chr. Chromosome 2 (human) Band 2q36.3 Start 227,813,842 bp End 227,817,564 bp
Gene location (Mouse) Chr. Chromosome 1 (mouse) Band 1 C5|1 42.69 cM Start 83,116,766 bp End 83,119,167 bp
RNA expression pattern More reference expression data
Gene ontology Molecular function • cytokine activity • protein binding • CCR6 chemokine receptor binding • chemokine activity Cellular component • extracellular region • intracellular • extracellular space Biological process • monocyte chemotaxis • positive regulation of T cell migration • neutrophil chemotaxis • positive regulation of ERK1 and ERK2 cascade • positive regulation of GTPase activity • positive regulation of nitric-oxide synthase biosynthetic process • defense response to bacterium • cell-cell signaling • lymphocyte chemotaxis • wound healing • cellular response to lipoteichoic acid • cellular response to tumor necrosis factor • cellular response to organic substance • chemokine-mediated signaling pathway • cellular response to interleukin-1 • cellular response to interferon-gamma • signal transduction • positive regulation of interleukin-1 alpha biosynthetic process • immune response • cellular response to lipopolysaccharide • chemotaxis • calcium-mediated signaling using intracellular calcium source • cell chemotaxis • T cell migration • thymocyte migration • inflammatory response • antimicrobial humoral immune response mediated by antimicrobial peptide • regulation of receptor activity • G-protein coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	6364	20297
Ensembl	ENSG00000115009	ENSMUSG00000026166
UniProt	P78556	O89093
RefSeq (mRNA)	NM_004591 NM_001130046	NM_001159738 NM_016960
RefSeq (protein)	NP_001123518 NP_004582	NP_001153210 NP_058656
Location (UCSC)	Chr 2: 227.81 – 227.82 Mb	Chr 2: 83.12 – 83.12 Mb
PubMed search

2JYO, 1M8A, 2HCI

6364

20297

ENSG00000115009

ENSMUSG00000026166

P78556

O89093

NM_004591
NM_001130046

NM_001159738
NM_016960

NP_001123518
NP_004582

NP_001153210
NP_058656

Chemokine (C-C motif) ligand 20 (CCL20) or liver activation regulated chemokine (LARC) or Macrophage Inflammatory Protein-3 (MIP3A) is a small cytokine belonging to the CC chemokine family. It is strongly chemotactic for lymphocytes and weakly attracts neutrophils. CCL20 is implicated in the formation and function of mucosal lymphoid tissues via chemoattraction of lymphocytes and dendritic cells towards the epithelial cells surrounding these tissues. CCL20 elicits its effects on its target cells by binding and activating the chemokine receptor CCR6.

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