MRF4

MYF6
Identifiers
Aliases	MYF6, CNM3, MRF4, bHLHc4, myf-6, Myf6, myogenic factor 6
External IDs	MGI: 97253 HomoloGene: 1850 GeneCards: MYF6
Gene ontology Molecular function • DNA binding • protein dimerization activity • transcription factor activity, sequence-specific DNA binding • transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding • RNA polymerase II core promoter proximal region sequence-specific DNA binding • E-box binding • protein heterodimerization activity • transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding Cellular component • nucleoplasm • RNA polymerase II transcription factor complex • nucleus Biological process • somitogenesis • cell differentiation • regulation of transcription, DNA-templated • positive regulation of muscle cell differentiation • regulation of transcription from RNA polymerase II promoter • muscle cell fate commitment • muscle organ development • transcription from RNA polymerase II promoter • positive regulation of skeletal muscle fiber development • multicellular organism development • positive regulation of transcription, DNA-templated • positive regulation of myoblast fusion • skeletal muscle tissue regeneration • positive regulation of myoblast differentiation • muscle tissue morphogenesis • skeletal muscle cell differentiation • negative regulation of transcription, DNA-templated • skeletal muscle tissue development • positive regulation of transcription from RNA polymerase II promoter Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	4618	17878
Ensembl	ENSG00000111046	ENSMUSG00000035923
UniProt	P23409	P15375
RefSeq (mRNA)	NM_002469	NM_008657
RefSeq (protein)	NP_002460	NP_032683.1 NP_032683
Location (UCSC)	Chr 12: 80.71 – 80.71 Mb	Chr 10: 107.49 – 107.49 Mb
PubMed search

4618

17878

ENSG00000111046

ENSMUSG00000035923

P23409

P15375

NM_002469

NM_008657

NP_002460

NP_032683.1
NP_032683

Myogenic factor 6 (herculin) is a protein that in humans is encoded by the MYF6 gene. Also known in the medical literature as MRF4 and herculin), MYF6 is a myogenic regulatory factor (MRF) in the process known as myogenesis.

MYF6 is a member of the myogenic factors (MYF) family that regulate myogenesis and muscle regeneration. Myogenic factor are basic helix-loop-helix (bHLH) transcription factors. Defects in this gene are a cause of autosomal dominant centronuclear myopathy (ADCNM).

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Wikipedia