MYL4

MYL4
Identifiers
Aliases	MYL4, ALC1, AMLC, GT1, PRO1957, myosin light chain 4
External IDs	MGI: 97267 HomoloGene: 20558 GeneCards: MYL4
Gene ontology Molecular function • calcium ion binding • actin filament binding • actin monomer binding • myosin II heavy chain binding Cellular component • cytosol • A band • myosin complex Biological process • positive regulation of ATPase activity • cardiac muscle contraction • regulation of the force of heart contraction • muscle filament sliding Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	4635	17896
Ensembl	ENSG00000198336	ENSMUSG00000061086
UniProt	P12829	P09541
RefSeq (mRNA)	NM_001002841 NM_002476	NM_010858
RefSeq (protein)	NP_001002841 NP_002467	n/a
Location (UCSC)	Chr 17: 47.2 – 47.22 Mb	Chr 11: 104.55 – 104.6 Mb
PubMed search

4635

17896

ENSG00000198336

ENSMUSG00000061086

P12829

P09541

NM_001002841
NM_002476

NM_010858

NP_001002841
NP_002467

n/a

Atrial Light Chain-1 (ALC-1), also known as Essential Light Chain, Atrial is a protein that in humans is encoded by the MYL4 gene. ALC-1 is expressed in fetal cardiac ventricular and fetal skeletal muscle, as well as fetal and adult cardiac atrial tissue. ALC-1 expression is reactivated in human ventricular myocardium in various cardiac muscle diseases, including hypertrophic cardiomyopathy, dilated cardiomyopathy, ischemic cardiomyopathy and congenital heart diseases.

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Wikipedia