MYOM2

MYOM2
Identifiers
Aliases	MYOM2, TTNAP, myomesin 2
External IDs	MGI: 1328358 HomoloGene: 2953 GeneCards: MYOM2
Gene location (Human) Chr. Chromosome 8 (human) Band 8p23.3 Start 2,045,040 bp End 2,165,552 bp
Gene location (Mouse) Chr. Chromosome 8 (mouse) Band 8|8 A1.1 Start 15,057,653 bp End 15,133,541 bp
RNA expression pattern More reference expression data
Gene ontology Molecular function • structural constituent of muscle • protein binding • actin filament binding • muscle alpha-actinin binding • structural molecule activity conferring elasticity • kinase binding Cellular component • cytoplasm • myosin filament • mitochondrion • muscle myosin complex • Z disc • M band Biological process • muscle contraction • extraocular skeletal muscle development • striated muscle contraction • actin filament organization • sarcomere organization • striated muscle myosin thick filament assembly Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	9172	17930
Ensembl	ENSG00000274137 ENSG00000036448	ENSMUSG00000031461
UniProt	P54296	n/a
RefSeq (mRNA)	NM_003970	NM_008664
RefSeq (protein)	NP_003961	n/a
Location (UCSC)	Chr 8: 2.05 – 2.17 Mb	Chr 8: 15.06 – 15.13 Mb
PubMed search

9172

17930

ENSG00000274137
ENSG00000036448

ENSMUSG00000031461

P54296

n/a

NM_003970

NM_008664

NP_003961

n/a

M-protein, also known as Myomesin-2 is a protein that in humans is encoded by the MYOM2 gene. M-protein is expressed in adult cardiac muscle and fast skeletal muscle, and functions to stabilize the three-dimensional arrangement of proteins comprising M-band structures.

Human M-protein is 165.0 kDa and 1465 amino acids in length.MYOM2 is localized to the human chromosome 8p23.3. M-protein belong to the superfamily of cytoskeletal proteins having immunoglobulin/fibronectin repeats; M-protein contains two immunoglobulin C2-type repeats in the N-terminal region, five fibronectin type III repeats in the central region, and an additional four immunoglobulin C2-type repeats in the C-terminal region. M-protein is expressed only in striated muscle, including fast skeletal muscle and cardiac muscle.

...
Wikipedia