Malin to Mizen most commonly refers to a journey from Malin Head (Ireland's most northerly point in County Donegal) to Mizen Head in County Cork (commonly thought to be Ireland's most southerly point, although nearby Brow Head is approximately 9 metres further south). The journey is most often attempted by cyclists and walkers as a challenge route with the goal of raising money for charities. As the crow flies, the two points are 466 km (290 mi) apart. The shortest road distance from Malin to Mizen is approximately 612 km (380 mi). The distance of the routes commonly taken have been reported as between 644 and 715 km (400 and 444 miles).
A record cycling time of 19 hours 3 mins was set in 1993 by Alex Barry. However, the route is most commonly completed in around 5–6 days by cyclists.
The charity Marie Curie Cancer Care uses the route as a fundraising opportunity and provides logistical support for cyclists who are able to raise a minimum sponsorship amount and pay a registration fee. In July 2014, 26 members of the Over The Hill Cycling Club from Watergrasshill in County Cork completed the cycle from Mizen Head to Malin Head in 23 hours ( 21:16:15 moving time). The cycle was organised to raise funds for Pieta House, the centre for the prevention of self-harm or suicide. CLIC Sargent, the children and young peoples cancer charity, also holds a Malin to Mizen cycle challenge, as does the Neurofibromatosis Association of Ireland, where again logistical support and accommodation are provided for cyclists who raise a minimum sponsorship amount. Between 3–5 August 2012, Irish Ultra-Distance Cyclist Ricky Geoghegan became the first person to cycle non-stop from Malin Head to Mizen Head and back to Malin Head on a route of 773.2 miles, setting an Ultra Marathon Cycling Association Record (UMCA) with a time of 2 days, 7 hours, and 37 minutes.
The route was attempted by a resident of Tyrone Robbie Lowe on 1.2-metre (4 foot) stilts in 1997 as a charity fundraising venture.
In 2002, Vinnie Kelly and Danny Farren from the nearby community of Glengad walked from Mizen to Malin in 12 days. They raised over €45,000 for local charities. Stephen O'Reilly Mariead Rooney and Ciara 'O'Hara walked from Malin head to Mizen over two-week in 2009 to raise money for Marie Curie.