Mary-Dell Chilton
| Mary-Dell Chilton | |
|---|---|
| Born | February 2, 1939 |
| Institutions | Syngenta Biotechnology Inc |
| Alma mater | University of Illinois at Urbana–Champaign |
| Thesis | Transforming Activity in Single-Stranded DNA from Bacillus subtilis (1967) |
| Doctoral advisor | Benjamin D. Hall |
| Notable students | Michael W. Bevan |
| Known for | First genetically modified plants |
| Notable awards | World Food Prize, National Inventors Hall of Fame |
Mary-Dell Chilton (born February 2, 1939, in Indianapolis, Indiana) is one of the founders of modern plant biotechnology.
Chilton attended private school for her early education. She earned both a B.S. and Ph.D. in chemistry from the University of Illinois. She later completed postdoctoral work at the University of Washington at Seattle.
Chilton taught and performed research at Washington University in St. Louis. While on faculty there in the late 1970s and early 1980s, she led a collaborative research study that produced the first transgenic plants.
Chilton was the first (1977) to demonstrate the presence of a fragment of Agrobacterium Ti plasmid DNA in the nuclear DNA of crown gall tissue. Her research on Agrobacterium also showed that the genes responsible for causing disease could be removed from the bacterium without adversely affecting its ability to insert its own DNA into plant cells and modify the plant's genome. Chilton described what she had done as disarming the bacterial plasmid responsible for the DNA transfer. She and her collaborators produced the first genetically modified plants using Agrobacterium carrying the disarmed Ti plasmid (1983). She has been called the "queen of Agrobacterium."
Chilton is author of more than 100 scientific publications. She is a Distinguished Science Fellow at Syngenta Biotechnology, Inc. She began her corporate career in 1983 with CIBA-Geigy Corporation (a legacy company of Syngenta).
For her work with Agrobacterium tumefaciens, she has been recognized with an honorary doctorate from the University of Louvaine, the John Scott Medal from the City of Philadelphia, membership in the United States National Academy of Sciences, and the Benjamin Franklin Medal in Life Sciences from the Franklin Institute.
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