Melanoma-associated chondroitin sulfate proteoglycan

CSPG4
Identifiers
Aliases	CSPG4, HMW-MAA, MCSP, MCSPG, MEL-CSPG, MSK16, NG2, chondroitin sulfate proteoglycan 4
External IDs	MGI: 2153093 HomoloGene: 20445 GeneCards: CSPG4
Gene location (Human) Chr. Chromosome 15 (human) Band 15q24.2 Start 75,674,322 bp End 75,712,848 bp
Gene location (Mouse) Chr. Chromosome 9 (mouse) Band 9|9 B Start 56,865,033 bp End 56,899,870 bp
RNA expression pattern More reference expression data
Gene ontology Molecular function • signal transducer activity • protein kinase binding Cellular component • integral component of membrane • cell projection • membrane • focal adhesion • plasma membrane • integral component of plasma membrane • extracellular region • cell surface • lysosomal lumen • apical plasma membrane • Golgi lumen • extracellular exosome • lamellipodium membrane • extracellular matrix Biological process • glycosaminoglycan metabolic process • cell differentiation • intracellular signal transduction • transmembrane receptor protein tyrosine kinase signaling pathway • chondroitin sulfate biosynthetic process • multicellular organism development • activation of MAPK activity • angiogenesis • positive regulation of peptidyl-tyrosine phosphorylation • chondroitin sulfate catabolic process • dermatan sulfate biosynthetic process • cell proliferation • tissue remodeling • signal transduction • glial cell migration Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	1464	121021
Ensembl	ENSG00000173546	ENSMUSG00000032911
UniProt	Q6UVK1	Q8VHY0
RefSeq (mRNA)	NM_001897	NM_139001
RefSeq (protein)	NP_001888	NP_620570
Location (UCSC)	Chr 15: 75.67 – 75.71 Mb	Chr 15: 56.87 – 56.9 Mb
PubMed search

1464

121021

ENSG00000173546

ENSMUSG00000032911

Q6UVK1

Q8VHY0

NM_001897

NM_139001

NP_001888

NP_620570

Chondroitin sulfate proteoglycan 4, also known as melanoma-associated chondroitin sulfate proteoglycan (MCSP) or neuron-glial antigen 2 (NG2), is a chondroitin sulfate proteoglycan that in humans is encoded by the CSPG4 gene.

CSPG4 plays a role in stabilizing cell-substratum interactions during early events of melanoma cell spreading on endothelial basement membranes. It represents an integral membrane chondroitin sulfate proteoglycan expressed by human malignant melanoma cells.

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