Millersburg is an unincorporated community in Callaway County, in the U.S. state of Missouri.
Millersburg was platted in 1829. The community derives its name from Thomas Miller, a pioneer settler. A post office called Millersburg was established in 1830, and remained in operation until 1953.
Coordinates: 38°53′55″N 92°07′25″W / 38.89861°N 92.12361°W