Monod equation
The Monod equation is a mathematical model for the growth of microorganisms. It is named for Jacques Monod who proposed using an equation of this form to relate microbial growth rates in an aqueous environment to the concentration of a limiting nutrient. The Monod equation has the same form as the Michaelis–Menten equation, but differs in that it is empirical while the latter is based on theoretical considerations.
The Monod equation is commonly used in environmental engineering. For example, it is used in the activated sludge model for sewage treatment.
The Monod equation is:
where:
μmax and Ks are empirical coefficients to the Monod equation. They will differ between species and based on the ambient environmental conditions.
The rate of substrate utilization is related to the specific growth rate as follows:
where:
rsu is negative by convention.
In some applications, multiple terms of the form [S/(Ks + S)] are multiplied together where more than one nutrient or growth factor has the potential to be limiting (e.g. organic matter and oxygen are both necessary to Heterotrophic bacteria). Yield coefficient, being ratio of mass of microorganisms to mass of substrate utilized, when becomes very large signifies that there is deficiency of substrate available for utilization.
As with the Michaelis–Menten equation graphical methods may be used to fit the coefficients of the Monod equation:
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