Mothers against decapentaplegic homolog 2

SMAD2

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
1DEV, 1KHX, 1U7V, 2LB3

Identifiers

Aliases

SMAD2, JV18, JV18-1, MADH2, MADR2, hMAD-2, hSMAD family member 2

External IDs

OMIM: 601366 MGI: 108051 HomoloGene: 21197 GeneCards: SMAD2

Gene ontology
Molecular function	• phosphatase binding • I-SMAD binding • transcription factor activity, sequence-specific DNA binding • transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding • transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity • enhancer binding • R-SMAD binding • co-SMAD binding • transcription factor binding • activating transcription factor binding • metal ion binding • RNA polymerase II core promoter proximal region sequence-specific DNA binding • transforming growth factor beta receptor binding • type I transforming growth factor beta receptor binding • protein homodimerization activity • chromatin binding • protein binding • double-stranded DNA binding • SMAD binding • DNA binding • protein heterodimerization activity • ubiquitin protein ligase binding • primary miRNA binding • disordered domain specific binding
Cellular component	• cytoplasm • cytosol • nucleus • SMAD2-SMAD3 protein complex • nuclear chromatin • SMAD protein complex • transcription factor complex • intracellular • nucleoplasm • activin responsive factor complex • protein complex
Biological process	• pattern specification process • ureteric bud development • endoderm development • response to cholesterol • organ growth • embryonic pattern specification • zygotic specification of dorsal/ventral axis • post-embryonic development • protein phosphorylation • pericardium development • regulation of binding • transforming growth factor beta receptor signaling pathway • negative regulation of cell proliferation • cell fate commitment • common-partner SMAD protein phosphorylation • regulation of transcription, DNA-templated • SMAD protein signal transduction • lung development • signal transduction involved in regulation of gene expression • insulin secretion • in utero embryonic development • negative regulation of transforming growth factor beta receptor signaling pathway • negative regulation of gene expression • nodal signaling pathway • positive regulation of transcription, DNA-templated • heart development • pancreas development • endoderm formation • activin receptor signaling pathway • SMAD protein complex assembly • palate development • positive regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry • embryonic foregut morphogenesis • negative regulation of transcription from RNA polymerase II promoter • response to glucose • positive regulation of epithelial to mesenchymal transition • developmental growth • gastrulation • primary miRNA processing • positive regulation of BMP signaling pathway • embryonic cranial skeleton morphogenesis • negative regulation of transcription, DNA-templated • paraxial mesoderm morphogenesis • intracellular signal transduction • somatic stem cell population maintenance • mesoderm formation • regulation of transforming growth factor beta receptor signaling pathway • positive regulation of gene expression • anterior/posterior pattern specification • positive regulation of transcription from RNA polymerase II promoter • transcription, DNA-templated • transcription from RNA polymerase II promoter • protein deubiquitination • wound healing
Sources:Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

Entrez


4087


17126

Ensembl


ENSG00000175387


ENSMUSG00000024563

UniProt


Q15796


Q62432

RefSeq (mRNA)


NM_001003652 NM_001135937 NM_005901


NM_001252481 NM_010754 NM_001311070

RefSeq (protein)


NP_001003652 NP_001129409 NP_005892


NP_001239410 NP_001297999 NP_034884

Location (UCSC)

Chr 18: 47.81 – 47.93 Mb

Chr 18: 76.24 – 76.31 Mb

PubMed search

1DEV, 1KHX, 1U7V, 2LB3

NM_001003652
NM_001135937
NM_005901

NM_001252481
NM_010754
NM_001311070

NP_001003652
NP_001129409
NP_005892

NP_001239410
NP_001297999
NP_034884

...
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