Muscarinic acetylcholine receptor M2

CHRM2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3UON, 4MQS, 4MQT
Identifiers
Aliases	CHRM2, HM2, cholinergic receptor muscarinic 2
External IDs	MGI: 88397 HomoloGene: 20190 GeneCards: CHRM2
Targeted by Drug
acetylcholine, arecoline, bethanechol, xanomeline, pilocarpine, brucine, vinburnine, vincamine, staurosporine, aclidinium, AFDX384, amitriptyline, biperiden, dexetimide, dicyclomine, hexocyclium, himbacine, imipramine, methoctramine free base, oxybutynin, pirenzepine, propantheline, clidinium, 3-quinuclidinyl-benzilate, , glycopyrrolate, darifenacin, tolterodine, oxotremorine
Gene ontology Molecular function • G-protein coupled receptor activity • signal transducer activity • drug binding • G-protein coupled acetylcholine receptor activity Cellular component • axon terminus • integral component of membrane • postsynaptic membrane • membrane • plasma membrane • synapse • integral component of plasma membrane • cell junction • neuronal cell body • dendrite • symmetric synapse • asymmetric synapse • clathrin-coated vesicle membrane Biological process • G-protein coupled acetylcholine receptor signaling pathway • G-protein coupled receptor signaling pathway • regulation of smooth muscle contraction • adenylate cyclase-modulating G-protein coupled receptor signaling pathway • G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger • response to virus • synaptic transmission, cholinergic • nervous system development • adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway • phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway • signal transduction • membrane organization • regulation of heart contraction Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	1129	243764
Ensembl	ENSG00000181072	ENSMUSG00000045613
UniProt	P08172	Q9ERZ4
RefSeq (mRNA)	NM_000739 NM_001006626 NM_001006627 NM_001006628 NM_001006629 NM_001006630 NM_001006631 NM_001006632 NM_001006633	NM_203491
RefSeq (protein)	NP_000730 NP_001006627 NP_001006628 NP_001006629 NP_001006630 NP_001006631 NP_001006632 NP_001006633	NP_987076.2 NP_987076
Location (UCSC)	Chr 7: 136.87 – 137.02 Mb	Chr 6: 36.39 – 36.53 Mb
PubMed search

3UON, 4MQS, 4MQT

1129

243764

ENSG00000181072

ENSMUSG00000045613

P08172

Q9ERZ4

NM_001006630
NM_001006631
NM_001006632
NM_001006633

NM_203491

NP_001006631
NP_001006632
NP_001006633

NP_987076.2
NP_987076

The muscarinic acetylcholine receptor M₂, also known as the cholinergic receptor, muscarinic 2, is a muscarinic acetylcholine receptor that in humans is encoded by the CHRM2 gene. Multiple alternatively spliced transcript variants have been described for this gene.

...
Wikipedia