NAA15

NAA15
Identifiers
Aliases	NAA15, Ga19, NARG1, NAT1P, NATH, TBDN, TBDN100, N(alpha)-acetyltransferase 15, NatA auxiliary subunit
External IDs	MGI: 1922088 HomoloGene: 14211 GeneCards: NAA15
Gene ontology Molecular function • protein binding • peptide alpha-N-acetyltransferase activity • acetyltransferase activity • ribosome binding • RNA binding Cellular component • NatA complex • transcription factor complex • nucleus • membrane • cytoplasm • cytosol Biological process • regulation of transcription, DNA-templated • N-terminal peptidyl-methionine acetylation • protein stabilization • multicellular organism development • positive regulation of transcription, DNA-templated • cell differentiation • angiogenesis • negative regulation of apoptotic process • N-terminal protein amino acid acetylation • GO:0006350 transcription, DNA-templated Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	80155	74838
Ensembl	ENSG00000164134	ENSMUSG00000063273
UniProt	Q9BXJ9	Q80UM3
RefSeq (mRNA)	NM_057175	NM_053089
RefSeq (protein)	NP_476516	n/a
Location (UCSC)	Chr 4: 139.3 – 139.42 Mb	Chr 3: 51.42 – 51.48 Mb
PubMed search

80155

74838

ENSG00000164134

ENSMUSG00000063273

Q9BXJ9

Q80UM3

NM_057175

NM_053089

NP_476516

n/a

N-alpha-acetyltransferase 15, NatA auxiliary subunit also known as gastric cancer antigen Ga19 (GA19), NMDA receptor-regulated protein 1 (NARG1), and Tbdn100 is a protein that in humans is encoded by the NAA15 gene. NARG1 is the auxiliary subunit of the NatA (N^α-acetyltransferase A) complex. This NatA complex can associate with the ribosome and catalyzes the transfer of an acetyl group to the N^α-terminal amino group of proteins as they emerge from the exit tunnel.

Human NAA15 is located on chromosome 4q31.1 and contains 23 exons. Initially, 2 mRNA species were identified, of size 4.6 and 5.8 kb, both harboring the same open reading frame encoding a putative protein of 866 amino acids (~105 kDa) protein that can be detected in most human adult tissues. According to RefSeq/NCBI, only one human transcript variant exists, although 2 more isoforms are predicted. In addition to full length Naa15, an N-terminally truncated variant of Naa15 (named tubedown-1), Naa15_273-865 has been described; however, in mouse only full length Naa15 is widely expressed, whereas smaller transcripts seem to visualized only in heart and testis.

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