NFYB

NFYB
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1N1J, 4AWL, 4CSR
Identifiers
Aliases	NFYB, CBF-A, CBF-B, HAP3, NF-YB, nuclear transcription factor Y subunit beta
External IDs	MGI: 97317 HomoloGene: 38149 GeneCards: NFYB
Gene ontology Molecular function • transcription factor activity, sequence-specific DNA binding • protein complex binding • sequence-specific DNA binding • repressing transcription factor binding • protein binding • protein heterodimerization activity • transcription regulatory region DNA binding • DNA binding Cellular component • protein-DNA complex • nucleoplasm • CCAAT-binding factor complex • nucleus Biological process • positive regulation of transcription, DNA-templated • GO:0006350 transcription, DNA-templated • regulation of transcription, DNA-templated • regulation of cholesterol biosynthetic process Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	4801	18045
Ensembl	ENSG00000120837	ENSMUSG00000020248
UniProt	P25208	P63139
RefSeq (mRNA)	NM_006166	NM_010914
RefSeq (protein)	NP_006157 NP_006157.1	NP_035044.1 NP_035044
Location (UCSC)	Chr 12: 104.12 – 104.14 Mb	Chr 10: 82.75 – 82.76 Mb
PubMed search

1N1J, 4AWL, 4CSR

4801

18045

ENSG00000120837

ENSMUSG00000020248

P25208

P63139

NM_006166

NM_010914

NP_006157
NP_006157.1

NP_035044.1
NP_035044

Nuclear transcription factor Y subunit beta is a protein that in humans is encoded by the NFYB gene.

The protein encoded by this gene is one subunit of a trimeric complex, forming a highly conserved transcription factor that binds with high specificity to CCAAT motifs in the promoter regions in a variety of genes. This gene product, subunit B, forms a tight dimer with the C subunit, a prerequisite for subunit A association. The resulting trimer binds to DNA with high specificity and affinity. Subunits B and C each contain a histone-like motif. Observation of the histone nature of these subunits is supported by two types of evidence; protein sequence alignments and experiments with mutants.

...
Wikipedia