NR1D2

NR1D2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4N73, 2V0V, 2V7C, 3CQV
Identifiers
Aliases	NR1D2, BD73, EAR-1R, RVR, nuclear receptor subfamily 1 group D member 2
External IDs	OMIM: 602304 MGI: 2449205 HomoloGene: 3763 GeneCards: NR1D2
Gene location (Human) Chr. Chromosome 3 (human) Band 3p24.2 Start 23,945,260 bp End 23,980,618 bp
Gene location (Mouse) Chr. Chromosome 14 (mouse) Band 14|14 A2 Start 18,204,054 bp End 18,239,127 bp
RNA expression pattern More reference expression data
Gene ontology Molecular function • DNA binding • sequence-specific DNA binding • transcription factor activity, sequence-specific DNA binding • zinc ion binding • metal ion binding • steroid hormone receptor activity • RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding • core promoter sequence-specific DNA binding • protein binding • RNA polymerase II distal enhancer sequence-specific DNA binding • transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding Cellular component • nucleus • nucleoplasm Biological process • regulation of transcription, DNA-templated • regulation of skeletal muscle cell differentiation • rhythmic process • transcription, DNA-templated • positive regulation of transcription, DNA-templated • regulation of lipid metabolic process • regulation of circadian rhythm • regulation of inflammatory response • lipid homeostasis • transcription initiation from RNA polymerase II promoter • negative regulation of transcription, DNA-templated • steroid hormone mediated signaling pathway • regulation of energy homeostasis • intracellular receptor signaling pathway • negative regulation of transcription from RNA polymerase II promoter Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	9975	353187
Ensembl	ENSG00000174738	ENSMUSG00000021775
UniProt	Q14995 Q6NSM0	Q60674
RefSeq (mRNA)	NM_001145425 NM_005126	NM_011584
RefSeq (protein)	NP_001138897 NP_005117	NP_035714
Location (UCSC)	Chr 3: 23.95 – 23.98 Mb	Chr 3: 18.2 – 18.24 Mb
PubMed search

4N73, 2V0V, 2V7C, 3CQV

9975

353187

ENSG00000174738

ENSMUSG00000021775

Q14995
Q6NSM0

Q60674

NM_001145425
NM_005126

NM_011584

NP_001138897
NP_005117

NP_035714

Rev-ErbA beta (Rev-erbβ) also known as NR1D2 (nuclear receptor subfamily 1, group D, member 2) is a protein that in humans is encoded by the NR1D2 gene.

Rev-erbβ is a member of the Rev-ErbA family of transcription factors. Rev-erbβ, like Rev-erbα, belongs to the nuclear receptor superfamily and can modulate gene expression by directly binding to their promoters.

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Wikipedia