NYX (gene)

NYX
Identifiers
Aliases	NYX, CLRP, CSNB1, CSNB1A, CSNB4, NBM1, nyctalopin
External IDs	MGI: 2448607 HomoloGene: 11210 GeneCards: NYX
Gene ontology Molecular function • protein kinase inhibitor activity Cellular component • cytoplasm • proteinaceous extracellular matrix • extracellular region • intracellular Biological process • negative regulation of protein kinase activity • response to stimulus • visual perception • cytokine-mediated signaling pathway • negative regulation of JAK-STAT cascade Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	60506	236690
Ensembl	ENSG00000188937	ENSMUSG00000051228
UniProt	Q9GZU5	P83503
RefSeq (mRNA)	NM_022567	NM_173415
RefSeq (protein)	NP_072089	NP_775591.1 NP_775591
Location (UCSC)	Chr X: 41.45 – 41.48 Mb	Chr X: 13.47 – 13.49 Mb
PubMed search

60506

236690

ENSG00000188937

ENSMUSG00000051228

Q9GZU5

P83503

NM_022567

NM_173415

NP_072089

NP_775591.1
NP_775591

Nyctalopin is a protein that in humans is encoded by the NYX gene. It is a leucine-rich proteoglycan which is expressed in the eye, spleen and brain in mice. Mutations in this gene cause congenital stationary night blindness in humans. A mouse strain called nob (no b-wave) carries a spontaneous mutation leading to a frameshift in this gene. These mice are used as an animal model for congenital stationary night blindness.

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Wikipedia