Nebulin

NEB
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 1NEB, 1ARK
Identifiers
Aliases	NEB, nebulin, NEB177D, NEM2
External IDs	MGI: 97292 HomoloGene: 136285 GeneCards: NEB
Gene ontology Molecular function • actin binding • structural constituent of muscle • protein binding Cellular component • cytoplasm • cytosol • sarcomere • Z disc • extracellular exosome • cytoskeleton • actin cytoskeleton Biological process • muscle filament sliding • muscle organ development • somatic muscle development • regulation of actin filament length Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	4703	17996
Ensembl	ENSG00000183091	ENSMUSG00000026950
UniProt	P20929 Q05C45	n/a
RefSeq (mRNA)	NM_001164507 NM_001164508 NM_001271208 NM_004543	NM_010889
RefSeq (protein)	NP_001157979 NP_001157980 NP_001258137 NP_004534 NP_004534.2	n/a
Location (UCSC)	Chr 2: 151.49 – 151.73 Mb	Chr 2: 52.14 – 52.38 Mb
PubMed search

1NEB, 1ARK

4703

17996

ENSG00000183091

ENSMUSG00000026950

P20929
Q05C45

n/a

NM_001164507
NM_001164508
NM_001271208
NM_004543

NM_010889

NP_001157979
NP_001157980
NP_001258137
NP_004534
NP_004534.2

n/a

Nebulin is an actin-binding protein which is localized to the thin filament of the sarcomeres in skeletal muscle. It is a very large protein (600–900 kDa) and binds as many as 200 actin monomers. Because its length is proportional to thin filament length, it is believed that nebulin acts as a thin filament "ruler" and regulates thin filament length during sarcomere assembly. Other functions of nebulin, such as a role in cell signaling, remain uncertain.

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