| Country | Serbia |
|---|---|
| Folded | 2014 |
| Number of teams | 16 (2006–2007) 18 (2007–2010) 16 (2010–2014) |
| Level on pyramid | 4 |
| Promotion to | Serbian League East |
| Relegation to |
Jablanica District League Niš First League Nišava District League Pčinja District League Pirot District League Toplica District League |
| Domestic cup(s) | Serbian Cup |
| Last champions |
Radan Lebane (2013–14) |
Niš Zone League (Serbian: Нишка зона / Niška zona) was one of eight sections of the Serbian Zone League, the fourth national tier.
The league was abolished in 2014, together with the Pomoravlje-Timok Zone League. Three new sections were established instead, the Zone League East, Zone League South and the Zone League West.