Nicotinamide phosphoribosyltransferase

NAMPT
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2E5B, 2E5C, 2E5D, 2GVG, 2GVJ, 3DGR, 3DHD, 3DHF, 3DKJ, 3DKL, 4JNM, 4JR5, 4KFN, 4KFO, 4KFP, 4L4L, 4L4M, 4LTS, 4LV9, 4LVA, 4LVB, 4LVD, 4LVF, 4LVG, 4LWW, 4M6P, 4M6Q, 4N9B, 4N9C, 4N9D, 4N9E, 4O0Z, 4O10, 4O12, 4O13, 4O14, 4O15, 4O16, 4O17, 4O18, 4O19, 4O1A, 4O1B, 4O1C, 4O1D, 4O28, 4WQ6
Identifiers
Aliases	NAMPT, 1110035O14Rik, PBEF, PBEF1, VF, VISFATIN, nicotinamide phosphoribosyltransferase
External IDs	MGI: 1929865 HomoloGene: 4201 GeneCards: NAMPT
Gene ontology Molecular function • transferase activity • cytokine activity • protein homodimerization activity • transferase activity, transferring glycosyl groups • protein binding • nicotinate-nucleotide diphosphorylase (carboxylating) activity • drug binding • nicotinamide phosphoribosyltransferase activity Cellular component • cytoplasm • cytosol • extracellular region • cell junction • extracellular exosome • nucleus • extracellular space • nuclear speck Biological process • pyridine nucleotide biosynthetic process • insulin receptor signaling pathway • response to organic cyclic compound • NAD biosynthetic process • rhythmic process • female pregnancy • cell-cell signaling • positive regulation of nitric-oxide synthase biosynthetic process • circadian regulation of gene expression • circadian rhythm • positive regulation of cell proliferation • adipose tissue development • positive regulation of transcription from RNA polymerase II promoter • positive regulation of smooth muscle cell proliferation • signal transduction • NAD biosynthesis via nicotinamide riboside salvage pathway Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	10135	59027
Ensembl	ENSG00000105835	ENSMUSG00000020572
UniProt	P43490	Q99KQ4
RefSeq (mRNA)	NM_005746 NM_182790	NM_021524
RefSeq (protein)	NP_005737	NP_067499.2 NP_067499
Location (UCSC)	Chr 7: 106.25 – 106.29 Mb	Chr 12: 32.82 – 32.85 Mb
PubMed search

nicotinamide phosphoribosyltransferase
Identifiers
EC number	2.4.2.12
CAS number	9030-27-7
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / EGO
Search PMC articles PubMed articles NCBI proteins

Search
PMC	articles
PubMed	articles
NCBI	proteins

2E5B, 2E5C, 2E5D, 2GVG, 2GVJ, 3DGR, 3DHD, 3DHF, 3DKJ, 3DKL, 4JNM, 4JR5, 4KFN, 4KFO, 4KFP, 4L4L, 4L4M, 4LTS, 4LV9, 4LVA, 4LVB, 4LVD, 4LVF, 4LVG, 4LWW, 4M6P, 4M6Q, 4N9B, 4N9C, 4N9D, 4N9E, 4O0Z, 4O10, 4O12, 4O13, 4O14, 4O15, 4O16, 4O17, 4O18, 4O19, 4O1A, 4O1B, 4O1C, 4O1D, 4O28, 4WQ6

...
Wikipedia