Nucleophosmin

NPM1

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
2LLH, 2P1B, 2VXD

Identifiers

Aliases

NPM1, B23, NPM, nucleophosmin (nucleolar phosphoprotein B23, numatrin), nucleophosmin, nucleophosmin 1

External IDs

MGI: 106184 HomoloGene: 81697 GeneCards: NPM1

Gene ontology
Molecular function	• ribosomal large subunit binding • protein homodimerization activity • ribosomal small subunit binding • unfolded protein binding • transcription coactivator activity • protein kinase inhibitor activity • histone binding • Tat protein binding • NF-kappaB binding • protein binding • RNA binding • protein heterodimerization activity • nucleic acid binding • protein kinase binding • core promoter binding • RNA polymerase II transcription coactivator activity • transcription factor binding • activating transcription factor binding • rRNA binding • protein N-terminus binding
Cellular component	• cytoplasm • membrane • focal adhesion • spindle pole centrosome • intracellular ribonucleoprotein complex • nucleoplasm • microtubule organizing center • nucleolus • cytoskeleton • nucleus • protein-DNA complex • protein complex • granular component • centrosome • cytosol • large ribosomal subunit • small ribosomal subunit • nuclear speck
Biological process	• centrosome cycle • regulation of eIF2 alpha phosphorylation by dsRNA • positive regulation of cell cycle G2/M phase transition • negative regulation of centrosome duplication • regulation of centriole replication • response to stress • positive regulation of translation • CENP-A containing nucleosome assembly • positive regulation of transcription, DNA-templated • cell aging • positive regulation of NF-kappaB transcription factor activity • protein oligomerization • negative regulation of protein kinase activity by regulation of protein phosphorylation • regulation of endodeoxyribonuclease activity • regulation of endoribonuclease activity • ribosome assembly • intracellular protein transport • DNA repair • signal transduction • negative regulation of cell proliferation • nucleosome assembly • viral process • DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest • regulation of transcription from RNA polymerase II promoter • cellular response to UV • ribosomal large subunit export from nucleus • ribosomal small subunit export from nucleus • rRNA export from nucleus • cell volume homeostasis • nucleocytoplasmic transport • protein localization • positive regulation of cell proliferation • posttranscriptional regulation of gene expression • negative regulation of gene expression • regulation of centrosome duplication • positive regulation of centrosome duplication • cell growth • positive regulation of cellular biosynthetic process • positive regulation of protein ubiquitination • regulation of protein stability • ribosomal large subunit biogenesis • ribosomal small subunit biogenesis • negative regulation of apoptotic process • regulation of DNA damage response, signal transduction by p53 class mediator • positive regulation of protein kinase activity • positive regulation of transcription from RNA polymerase II promoter • negative regulation of mRNA splicing, via spliceosome • protein stabilization • protein homooligomerization • regulation of cell cycle • positive regulation of protein localization to nucleolus
Sources:Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

Entrez


4869


18148

Ensembl


ENSG00000181163


ENSMUSG00000057113

UniProt


P06748


Q61937

RefSeq (mRNA)


NM_001037738 NM_002520 NM_199185


NM_001252260 NM_001252261 NM_008722

RefSeq (protein)


NP_001032827 NP_002511 NP_954654


NP_001239189 NP_001239190 NP_032748

Location (UCSC)

Chr 5: 171.39 – 171.41 Mb

Chr 11: 33.15 – 33.16 Mb

PubMed search

2LLH, 2P1B, 2VXD

NM_001037738
NM_002520
NM_199185

NM_001252260
NM_001252261
NM_008722

NP_001032827
NP_002511
NP_954654

NP_001239189
NP_001239190
NP_032748

...
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