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First edition
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| Author | Isaac Asimov |
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| Country | United States |
| Language | English |
| Series | Fantasy & Science Fiction essays |
| Publisher | Doubleday |
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Publication date
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1975 |
| Media type | print (Hardback and Paperback) |
| ISBN | |
| Preceded by | The Tragedy of the Moon |
| Followed by | The Planet That Wasn't |
Of Matters Great and Small is a collection of seventeen scientific essays by Isaac Asimov. It was the eleventh of a series of books collecting essays from The Magazine of Fantasy and Science Fiction, although it also includes one essay from Science Digest. It was first published by Doubleday & Company in 1975.