Onondaga is an unincorporated community in Onondaga Township in the southwestern corner of Ingham County in the U.S. state of Michigan. It is situated on the Grand River at 42°26′39″N 84°33′44″W / 42.44417°N 84.56222°WCoordinates: 42°26′39″N 84°33′44″W / 42.44417°N 84.56222°W approximately 20 miles south of Lansing and approximately 15 mile northwest of Jackson.
European-American settlement began in the mid-19th century, with most migrants coming from New England and New York. The township and community were named after the Iroquois nation of Onondaga, historically based in New York. A post office was first established at the place about 1844, with Perez Howland as the first postmaster. In 1847 Perez Howland built a grocery. A post office was operated from the grocery. Cyrus Baldwin subsequently purchased the building and converted it into the "Onondaga Hotel".