Ornidazole

Ornidazole

Clinical data
Trade names	Xynor
AHFS/Drugs.com	International Drug Names
Routes of administration	Oral
ATC code	G01AF06 (WHO) J01XD03 (WHO) P01AB03 (WHO) QP51AA03 (WHO)
Pharmacokinetic data
Metabolism	Metabolized via the liver, excreted in the Urine and Feces
Excretion	85% of single oral dose is eliminated with 5 days - Urine (63%) and Feces (22%)
Identifiers
IUPAC name 1-Chloro-3-(2-methyl-5-nitro-1H-imidazol-1-yl)propan-2-ol
CAS Number	16773-42-5 Y
PubChem CID	28061
ChemSpider	26102 Y
UNII	62XCK0G93T
KEGG	D05274 Y
ChEBI	CHEBI:75176 N
ChEMBL	CHEMBL1449676 N
ECHA InfoCard	100.037.099
Chemical and physical data
Formula	C7H10ClN3O3
Molar mass	219.625 g/mol
3D model (Jmol)	Interactive image
SMILES [O-][N+](=O)c1cnc(n1CC(O)CCl)C
InChI InChI=1S/C7H10ClN3O3/c1-5-9-3-7(11(13)14)10(5)4-6(12)2-8/h3,6,12H,2,4H2,1H3 Y Key:IPWKIXLWTCNBKN-UHFFFAOYSA-N Y
NY (what is this?)

Ornidazole is a drug that cures some protozoan infections. It has been investigated for use in Crohn's disease after bowel resection.

Synthesis is a straightforward reaction between 2-methyl-nitroimidazole and epichlorohydrin under acid catalyst conditions.

After passive absorption into bacterium cell, the nitro group of ornidazole is reduced to amine group by ferrodoxin type redox system. The formation of redox intermediate intracellular metabolites is believed to be the key component of microorganism killing for Ornidazole. The drug is active against anaerobic bacteria viz. , Clostridium, B. fragilis, Prevotella, Porphyronomas, Fusobacterium and protozoa viz. E. histolytica, T. vaginalis, G. intestinalis etc.