Coordinates: 43°56′6.05″N 10°55′0.39″E / 43.9350139°N 10.9167750°E
Ospedale del Ceppo is a medieval hospital in Pistoia, Tuscany, central Italy.
According to tradition, the Ospedale was founded in 1277 by the company of Santa Maria or "del dei poveri" ("The offering trunk of the poor"). In 1345 documents mention ongoing works for a new cloister, oratory and domus (residence for women). It became the main city's hospital after the donations received in the wake of the Black Death of 1348. Initially given to the cathedral chapter, from 1350 the commune of Pistoia tried to absorb direction of the company. After the conquest of Pistoia by the Republic of Florence (1401), the Florentines officially confirmed the lay status of the hospital.
In 1456 the hospital administrators commissioned the Florentine architect Michelozzo di Bartolomeo a restoration of the building. The election of the spedalingo (rector) was often contended between the noble Pistoiese families, sometimes causing popular turmoil such as in 1498. In 1494 the Compagnia del Ceppo was expelled in 1494, the hospital administrated by the communal priori. In 1501 the hospital was submitted to the Hospital of Santa Maria Nuova in Florence; the Florentine spedalingo, Leonardo Buonafede, ordered in this period the realization of the frieze which is now the main feature of the monumental façade.
In 1784 Grand Duke Pietro Leopoldo of Tuscany aggregated the hospital to a new entity including the other Pistoiese hospital of San Gregorio, the Spedali Riuniti di Pistoia, the spedalingo returning to be a Pistoiese.