PALB2

PALB2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2W18, 3EU7
Identifiers
Aliases	PALB2, FANCN, PNCA3, partner and localizer of BRCA2
External IDs	MGI: 3040695 HomoloGene: 11652 GeneCards: PALB2
Gene ontology Molecular function • DNA binding • protein binding Cellular component • nucleoplasm • nucleus Biological process • animal organ morphogenesis • somitogenesis • post-anal tail morphogenesis • cellular response to DNA damage stimulus • DNA recombination • mesoderm development • negative regulation of apoptotic process • in utero embryonic development • multicellular organism growth • embryonic organ development • inner cell mass cell proliferation • DNA repair • DNA synthesis involved in DNA repair • double-strand break repair via homologous recombination • strand displacement Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	79728	233826
Ensembl	ENSG00000083093	ENSMUSG00000044702
UniProt	Q86YC2	Q3U0P1
RefSeq (mRNA)	NM_024675	NM_001081238 NM_001289842 NM_001289843 NM_001289844 NM_001289845 NM_172744
RefSeq (protein)	NP_078951	NP_001074707.1 NP_001276771.1 NP_001276772.1 NP_001276773.1 NP_001276774.1 NP_001074707 NP_001276771 NP_001276772 NP_001276773 NP_001276774
Location (UCSC)	Chr 16: 23.6 – 23.64 Mb	Chr 7: 122.11 – 122.13 Mb
PubMed search

2W18, 3EU7

79728

233826

ENSG00000083093

ENSMUSG00000044702

Q86YC2

Q3U0P1

NM_024675

NM_172744

NP_078951

NP_001074707
NP_001276771
NP_001276772
NP_001276773
NP_001276774

Partner and localizer of BRCA2, also known as PALB2 or FANCN, is a protein which in humans is encoded by the PALB2 gene.

This gene encodes a protein that functions in genome maintenance (double strand break repair). This protein binds to and colocalizes with the breast cancer 2 early onset protein (BRCA2) in nuclear foci and likely permits the stable intranuclear localization and accumulation of BRCA2. PALB2 binds the single strand DNA and directly interacts with the recombinase RAD51 to stimulate strand invasion, a vital step of homologous recombination, (see Figure "Homologous recombinational repair of DNA double-strand damage"). PALB2 can function synergistically with a BRCA2 chimera (termed piccolo, or piBRCA2) to further promote strand invasion.

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Wikipedia