PAR4

F2RL3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2ZPK, 3QDZ
Identifiers
Aliases	F2RL3, PAR4, F2R like thrombin/trypsin receptor 3, F2R like thrombin or trypsin receptor 3
External IDs	MGI: 1298207 HomoloGene: 36148 GeneCards: F2RL3
Gene location (Human) Chr. Chromosome 19 (human) Band 19p13.11 Start 16,888,860 bp End 16,892,606 bp
Gene location (Mouse) Chr. Chromosome 8 (mouse) Band n/a Start 72,761,880 bp End 72,763,874 bp
RNA expression pattern More reference expression data
Gene ontology Molecular function • thrombin-activated receptor activity • signal transducer activity • G-protein coupled receptor activity Cellular component • integral component of membrane • extracellular region • integral component of plasma membrane • membrane • plasma Biological process • platelet activation • hemostasis • phospholipase C-activating G-protein coupled receptor signaling pathway • thrombin-activated receptor signaling pathway • G-protein coupled receptor signaling pathway • positive regulation of release of sequestered calcium ion into cytosol • platelet dense granule organization • response to wounding • signal transduction • blood coagulation • positive regulation of Rho protein signal transduction • positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	9002	14065
Ensembl	ENSG00000127533	ENSMUSG00000050147
UniProt	Q96RI0	O88634
RefSeq (mRNA)	NM_003950	NM_007975
RefSeq (protein)	NP_003941	NP_032001
Location (UCSC)	Chr 19: 16.89 – 16.89 Mb	Chr 19: 72.76 – 72.76 Mb
PubMed search

2ZPK, 3QDZ

9002

14065

ENSG00000127533

ENSMUSG00000050147

Q96RI0

O88634

NM_003950

NM_007975

NP_003941

NP_032001

Protease-activated receptor 4 (PAR-4), also known as coagulation factor II (thrombin) receptor-like 3, is a protein that in humans is encoded by the F2RL3 gene.

Coagulation factor II (thrombin) receptor-like 3 (F2RL3) is a member of the large family of 7-transmembrane-region receptors that couple to guanosine-nucleotide-binding proteins. F2RL3 is also a member of the protease-activated receptor family. F2RL3 is activated by proteolytic cleavage of its extracellular amino terminus. The new amino terminus functions as a tethered ligand and activates the receptor. F2RL3 is activated by thrombin and trypsin.

...
Wikipedia