PLCB1

PLCB1
Identifiers
Aliases	PLCB1, EIEE12, PI-PLC, PLC-154, PLC-I, PLC154, PLCB1A, PLCB1B, PLC-beta-1, phospholipase C beta 1
External IDs	MGI: 97613 HomoloGene: 22876 GeneCards: PLCB1
Genetically Related Diseases
non-small-cell lung carcinoma
Gene ontology Molecular function • calcium ion binding • protein homodimerization activity • GTPase activator activity • signal transducer activity • calmodulin binding • protein binding • phosphoric diester hydrolase activity • enzyme binding • phosphatidylinositol-4,5-bisphosphate binding • hydrolase activity • lamin binding • phosphatidylinositol phospholipase C activity Cellular component • cytoplasm • cytosol • nuclear speck • nuclear membrane • membrane • myelin sheath • nuclear chromatin • extracellular exosome • nucleus Biological process • G-protein coupled acetylcholine receptor signaling pathway • glutamate receptor signaling pathway • insulin-like growth factor receptor signaling pathway • interleukin-15-mediated signaling pathway • intracellular signal transduction • positive regulation of developmental growth • phosphatidylinositol metabolic process • negative regulation of monocyte extravasation • positive regulation of interleukin-12 production • regulation of G-protein coupled receptor protein signaling pathway • lipid metabolic process • inositol phosphate metabolic process • positive regulation of JNK cascade • memory • regulation of cell cycle • positive regulation of transcription, DNA-templated • lipid catabolic process • positive regulation of G1/S transition of mitotic cell cycle • interleukin-1-mediated signaling pathway • positive regulation of acrosome reaction • brain development • G2/M transition of mitotic cell cycle • interleukin-12-mediated signaling pathway • positive regulation of myoblast differentiation • positive regulation of CD24 biosynthetic process • cerebral cortex development • activation of meiosis involved in egg activation • regulation of fertilization • positive regulation of embryonic development • negative regulation of transcription, DNA-templated • fat cell differentiation • signal transduction • Wnt signaling pathway, calcium modulating pathway • positive regulation of GTPase activity Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	23236	18795
Ensembl	ENSG00000182621	ENSMUSG00000051177
UniProt	Q9NQ66	Q9Z1B3
RefSeq (mRNA)	NM_015192 NM_182734	NM_001145830 NM_019677
RefSeq (protein)	NP_056007 NP_877398	NP_001139302.1 NP_062651.2 NP_001139302 NP_062651
Location (UCSC)	Chr 20: 8.08 – 8.97 Mb	Chr 2: 134.79 – 135.48 Mb
PubMed search

23236

18795

ENSG00000182621

ENSMUSG00000051177

Q9NQ66

Q9Z1B3

NM_015192
NM_182734

NM_001145830
NM_019677

NP_056007
NP_877398

NP_001139302.1
NP_062651.2
NP_001139302
NP_062651

1-Phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-1 is an enzyme that in humans is encoded by the PLCB1 gene.

The protein encoded by this gene catalyzes the formation of inositol 1,4,5-trisphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate. This reaction uses calcium as a cofactor and plays an important role in the intracellular transduction of many extracellular signals. This gene is activated by two G-protein alpha subunits, alpha-q and alpha-11. Two transcript variants encoding different isoforms have been found for this gene.

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