POLE4

POLE4
Identifiers
Aliases	POLE4, YHHQ1, p12, polymerase (DNA) epsilon 4, accessory subunit, DNA polymerase epsilon 4, accessory subunit
External IDs	MGI: 1914229 HomoloGene: 41339 GeneCards: POLE4
Gene ontology Molecular function • transferase activity • DNA binding • DNA-directed DNA polymerase activity • nucleotidyltransferase activity • protein binding • protein heterodimerization activity Cellular component • Ada2/Gcn5/Ada3 transcription activator complex • epsilon DNA polymerase complex • Q40260 • nucleoplasm Biological process • histone H3 acetylation • DNA biosynthetic process • G1/S transition of mitotic cell cycle • DNA replication initiation • telomere maintenance via semi-conservative replication Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	56655	66979
Ensembl	ENSG00000115350	ENSMUSG00000030042
UniProt	Q9NR33	Q9CQ36
RefSeq (mRNA)	NM_019896	NM_025882
RefSeq (protein)	NP_063949	NP_080158
Location (UCSC)	Chr 2: 74.96 – 74.97 Mb	Chr 6: 82.62 – 82.71 Mb
PubMed search

56655

66979

ENSG00000115350

ENSMUSG00000030042

Q9NR33

Q9CQ36

NM_019896

NM_025882

NP_063949

NP_080158

Polymerase (DNA-directed), epsilon 4, accessory subunit is a protein that in humans is encoded by the POLE4 gene.

POLE4 is a histone-fold protein that interacts with other histone-fold proteins to bind DNA in a sequence-independent manner. These histone-fold protein dimers combine within larger enzymatic complexes for DNA transcription, replication, and packaging.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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