POLE (gene)

POLE
Identifiers
Aliases	POLE, CRCS12, FILS, POLE1, polymerase (DNA) epsilon, catalytic subunit, DNA polymerase epsilon, catalytic subunit
External IDs	MGI: 1196391 HomoloGene: 4539 GeneCards: POLE
Gene location (Human) Chr. Chromosome 12 (human) Band 12q24.33 Start 132,623,753 bp End 132,687,365 bp
Gene location (Mouse) Chr. Chromosome 5 (mouse) Band n/a Start 110,286,306 bp End 110,337,474 bp
RNA expression pattern More reference expression data
Gene ontology Molecular function • transferase activity • nucleotide binding • DNA binding • 4 iron, 4 sulfur cluster binding • nucleotidyltransferase activity • iron-sulfur cluster binding • zinc ion binding • chromatin binding • metal ion binding • 3'-5' exonuclease activity • nucleic acid binding • DNA-directed DNA polymerase activity • single-stranded DNA 3'-5' exodeoxyribonuclease activity • protein binding Cellular component • plasma • nucleoplasm • nucleus • epsilon DNA polymerase complex Biological process • nucleotide-excision repair, DNA gap filling • DNA synthesis involved in DNA repair • DNA biosynthetic process • embryonic organ development • nucleic acid phosphodiester bond hydrolysis • cellular response to DNA damage stimulus • DNA replication initiation • base-excision repair, gap-filling • DNA repair • DNA replication • G1/S transition of mitotic cell cycle • leading strand elongation • DNA replication proofreading • telomere maintenance via semi-conservative replication Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	5426	18973
Ensembl	ENSG00000177084	ENSMUSG00000007080
UniProt	Q07864	Q9WVF7
RefSeq (mRNA)	NM_006231	NM_011132
RefSeq (protein)	NP_006222	NP_035262
Location (UCSC)	Chr 12: 132.62 – 132.69 Mb	Chr 12: 110.29 – 110.34 Mb
PubMed search

5426

18973

ENSG00000177084

ENSMUSG00000007080

Q07864

Q9WVF7

NM_006231

NM_011132

NP_006222

NP_035262

DNA polymerase epsilon catalytic subunit is an enzyme that in humans is encoded by the POLE gene. It is the central catalytic subunit of DNA polymerase epsilon.

POLE, along with POLD1, has recently been associated with multiple adenoma.

POLE has been shown to interact with RAD17.

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Wikipedia