PRKCD

PRKCD
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2YUU, 1YRK
Identifiers
Aliases	PRKCD, ALPS3, CVID9, MAY1, PKCD, nPKC-delta, protein kinase C delta
External IDs	OMIM: 176977 MGI: 97598 HomoloGene: 55963 GeneCards: PRKCD
EC number	2.7.10.2
Gene ontology Molecular function • kinase activity • ATP binding • protein kinase activity • non-membrane spanning protein tyrosine kinase activity • metal ion binding • kinase binding • enzyme binding • insulin receptor substrate binding • transferase activity • protein binding • calcium-independent protein kinase C activity • protein kinase binding • nucleotide binding • enzyme activator activity • protein serine/threonine kinase activity • protein kinase C activity Cellular component • cytoplasm • cytosol • membrane • cell-cell junction • perinuclear region of cytoplasm • nucleus • nuclear matrix • endoplasmic reticulum • extracellular exosome • plasma membrane • nucleoplasm • extracellular region • azurophil granule lumen Biological process • intrinsic apoptotic signaling pathway in response to oxidative stress • termination of signal transduction • interferon-gamma-mediated signaling pathway • negative regulation of protein binding • positive regulation of endodeoxyribonuclease activity • platelet activation • protein phosphorylation • cellular senescence • negative regulation of insulin receptor signaling pathway • positive regulation of sphingomyelin catabolic process • cell chemotaxis • cell cycle • negative regulation of inflammatory response • positive regulation of protein dephosphorylation • Fc-gamma receptor signaling pathway involved in phagocytosis • positive regulation of apoptotic signaling pathway • stimulatory C-type lectin receptor signaling pathway • activation of phospholipase C activity • cellular response to hydroperoxide • negative regulation of peptidyl-tyrosine phosphorylation • defense response to bacterium • negative regulation of MAP kinase activity • positive regulation of response to DNA damage stimulus • positive regulation of protein import into nucleus • interleukin-10 production • regulation of actin cytoskeleton organization • negative regulation of actin filament polymerization • regulation of mRNA stability • phosphorylation • protein stabilization • regulation of receptor activity • negative regulation of filopodium assembly • cellular response to angiotensin • interleukin-12 production • peptidyl-threonine phosphorylation • positive regulation of ceramide biosynthetic process • neutrophil activation • intracellular signal transduction • negative regulation of glial cell apoptotic process • negative regulation of platelet aggregation • positive regulation of phospholipid scramblase activity • histone phosphorylation • B cell proliferation • immunoglobulin mediated immune response • positive regulation of glucosylceramide catabolic process • peptidyl-tyrosine phosphorylation • positive regulation of superoxide anion generation • activation of protein kinase activity • signal transduction • cellular response to hydrogen peroxide • peptidyl-serine phosphorylation • apoptotic process • neutrophil degranulation • execution phase of apoptosis Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	5580	18753
Ensembl	ENSG00000163932	ENSMUSG00000021948
UniProt	Q05655	P28867
RefSeq (mRNA)	NM_006254 NM_212539 NM_001316327	NM_011103 NM_001310682
RefSeq (protein)	NP_001303256 NP_006245 NP_997704	NP_035233.1 NP_001297611 NP_035233
Location (UCSC)	Chr 3: 53.16 – 53.19 Mb	Chr 14: 30.6 – 30.63 Mb
PubMed search

2YUU, 1YRK

5580

18753

ENSG00000163932

ENSMUSG00000021948

Q05655

P28867

NM_006254
NM_212539
NM_001316327

NM_011103
NM_001310682

NP_001303256
NP_006245
NP_997704

NP_035233.1
NP_001297611
NP_035233

Protein kinase C delta type (or PKC-δ) is an enzyme that in humans is encoded by the PRKCD gene.

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