PRKCE

PRKCE
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2WH0
Identifiers
Aliases	PRKCE, PKCE, nPKC-epsilon, protein kinase C epsilon
External IDs	MGI: 97599 HomoloGene: 48343 GeneCards: PRKCE
Gene ontology Molecular function • transferase activity • nucleotide binding • protein kinase activity • protein kinase C activity • actin monomer binding • 14-3-3 protein binding • signal transducer activity • metal ion binding • receptor activator activity • protein serine/threonine kinase activity • kinase activity • protein binding • calcium-independent protein kinase C activity • enzyme binding • ethanol binding • enzyme activator activity • ATP binding Cellular component • cytoplasm • cell periphery • cytosol • Golgi apparatus • membrane • plasma membrane • endoplasmic reticulum • mitochondrion • perinuclear region of cytoplasm • cytoskeleton • nucleus Biological process • positive regulation of cell-substrate adhesion • release of sequestered calcium ion into cytosol • regulation of insulin secretion involved in cellular response to glucose stimulus • positive regulation of cellular glucuronidation • GO:0007242 intracellular signal transduction • positive regulation of actin filament polymerization • cellular response to ethanol • Fc-gamma receptor signaling pathway involved in phagocytosis • phosphorylation • immune system process • regulation of release of sequestered calcium ion into cytosol • negative regulation of sodium ion transmembrane transporter activity • positive regulation of lipid catabolic process • positive regulation of wound healing • positive regulation of epithelial cell migration • activation of phospholipase C activity • positive regulation of synaptic transmission, GABAergic • TRAM-dependent toll-like receptor 4 signaling pathway • locomotory exploration behavior • platelet activation • positive regulation of cytokinesis • cell division • negative regulation of protein ubiquitination • protein phosphorylation • macrophage activation involved in immune response • response to morphine • positive regulation of receptor activity • regulation of lipid metabolic process • cell adhesion • cellular response to prostaglandin E stimulus • peptidyl-serine phosphorylation • positive regulation of I-kappaB kinase/NF-kappaB signaling • cell cycle • positive regulation of mucus secretion • positive regulation of fibroblast migration • cellular response to hypoxia • lipopolysaccharide-mediated signaling pathway • signal transduction • positive regulation of insulin secretion • positive regulation of MAPK cascade • regulation of peptidyl-tyrosine phosphorylation • apoptotic process • positive regulation of protein localization to plasma membrane Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	5581	18754
Ensembl	ENSG00000171132	ENSMUSG00000045038
UniProt	Q02156	P16054
RefSeq (mRNA)	NM_005400	NM_011104
RefSeq (protein)	NP_005391	NP_035234.1 NP_035234
Location (UCSC)	Chr 2: 45.65 – 46.19 Mb	Chr 17: 86.17 – 86.66 Mb
PubMed search

2WH0

5581

18754

ENSG00000171132

ENSMUSG00000045038

Q02156

P16054

NM_005400

NM_011104

NP_005391

NP_035234.1
NP_035234

Protein kinase C epsilon type (PKCε) is an enzyme that in humans is encoded by the PRKCE gene. PKCε is an isoform of the large PKC family of protein kinases that play many roles in different tissues. In cardiac muscle cells, PKCε regulates muscle contraction through its actions at sarcomeric proteins, and PKCε modulates cardiac cell metabolism through its actions at . PKCε is clinically significant in that it a central player in cardioprotection against ischemic injury and in the development of cardiac hypertrophy.

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Wikipedia