PRKCI

PRKCI
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1VD2, 1WMH, 1ZRZ, 3A8W, 3A8X, 3ZH8
Identifiers
Aliases	PRKCI, DXS1179E, PKCI, nPKC-iota, protein kinase C iota
External IDs	MGI: 99260 HomoloGene: 37667 GeneCards: PRKCI
Gene ontology Molecular function • transferase activity • protein kinase activity • nucleotide binding • protein kinase C activity • protein domain specific binding • metal ion binding • kinase activity • protein serine/threonine kinase activity • protein binding • phospholipid binding • ATP binding Cellular component • cytosol • endosome • membrane • bicellular tight junction • microtubule cytoskeleton • Golgi membrane • plasma membrane • apical part of cell • Schmidt-Lanterman incisure • protein complex • apical plasma membrane • cell leading edge • intercellular bridge • extracellular exosome • nucleus • cytoplasm Biological process • negative regulation of neuron apoptotic process • positive regulation of glucose import • establishment of apical/basal cell polarity • intracellular signal transduction • response to interleukin-1 • phosphorylation • Golgi vesicle budding • actin filament organization • protein targeting to membrane • negative regulation of glial cell apoptotic process • response to peptide hormone • negative regulation of apoptotic process • secretion • protein phosphorylation • cellular protein localization • positive regulation of endothelial cell apoptotic process • positive regulation of NF-kappaB transcription factor activity • cytoskeleton organization • establishment or maintenance of epithelial cell apical/basal polarity • bicellular tight junction assembly • positive regulation of neuron projection development • cellular response to insulin stimulus • eye photoreceptor cell development • membrane organization • positive regulation of glial cell proliferation • cell migration • vesicle-mediated transport • cell-cell junction organization • peptidyl-serine phosphorylation • positive regulation of protein localization to plasma membrane Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	5584	18759
Ensembl	ENSG00000163558	ENSMUSG00000037643
UniProt	P41743	Q62074
RefSeq (mRNA)	NM_002740	NM_008857
RefSeq (protein)	NP_002731	NP_032883
Location (UCSC)	Chr 3: 170.22 – 170.31 Mb	Chr 3: 31 – 31.05 Mb
PubMed search

1VD2, 1WMH, 1ZRZ, 3A8W, 3A8X, 3ZH8

5584

18759

ENSG00000163558

ENSMUSG00000037643

P41743

Q62074

NM_002740

NM_008857

NP_002731

NP_032883

Protein kinase C iota type is an enzyme that in humans is encoded by the PRKCI gene.

This gene encodes a member of the protein kinase C (PKC) family of serine/threonine protein kinases. The PKC family comprises at least eight members, which are differentially expressed and are involved in a wide variety of cellular processes. This protein kinase is calcium-independent and phospholipid-dependent. It is not activated by phorbolesters or diacylglycerol. This kinase can be recruited to vesicle tubular clusters (VTCs) by direct interaction with the small GTPase RAB2, where this kinase phosphorylates glyceraldehyde-3-phosphate dehydrogenase (GAPD/GAPDH) and plays a role in microtubule dynamics in the early secretory pathway. This kinase is found to be necessary for BCL-ABL-mediated resistance to drug-induced apoptosis and therefore protects leukemia cells against drug-induced apoptosis. There is a single exon pseudogene mapped on chromosome X.

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