PRKD1

PRKD1
Identifiers
Aliases	PRKD1, PKC-MU, PKCM, PKD, PRKCM, Protein kinase D1, CHDED
External IDs	MGI: 99879 HomoloGene: 55680 GeneCards: PRKD1
Gene ontology Molecular function • transferase activity • nucleotide binding • protein kinase activity • protein kinase C activity • metal ion binding • kinase activity • protein serine/threonine kinase activity • protein binding • identical protein binding • ATP binding Cellular component • Golgi apparatus • membrane • plasma membrane • integral component of plasma membrane • autophagosome membrane • cytoplasm • trans-Golgi network • cytosol Biological process • negative regulation of endocytosis • cell differentiation • intracellular signal transduction • positive regulation of endothelial cell proliferation • regulation of protein stability • Golgi organization • phosphorylation • immune system process • positive regulation of endothelial cell chemotaxis • protein kinase D signaling • sphingolipid biosynthetic process • negative regulation of cell death • nervous system development • positive regulation of peptidyl-serine phosphorylation • positive regulation of angiogenesis • positive regulation of endothelial cell migration • protein phosphorylation • positive regulation of histone deacetylase activity • positive regulation of CREB transcription factor activity • vascular endothelial growth factor receptor signaling pathway • regulation of integrin-mediated signaling pathway • positive regulation of NF-kappaB transcription factor activity • peptidyl-serine phosphorylation • angiogenesis • positive regulation of blood vessel endothelial cell migration • positive regulation of neuron projection development • positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway • positive regulation of I-kappaB kinase/NF-kappaB signaling • integrin-mediated signaling pathway • protein autophosphorylation • cellular response to oxidative stress • cellular response to vascular endothelial growth factor stimulus • Ras protein signal transduction • cell proliferation • inflammatory response • innate immune response • signal transduction • positive regulation of transcription from RNA polymerase II promoter • apoptotic process • positive regulation of autophagy • peptidyl-threonine phosphorylation • cellular response to amino acid starvation • positive regulation of phosphatidylinositol 3-kinase activity • cellular response to hydroperoxide • regulation of keratinocyte proliferation • positive regulation of osteoblast differentiation • Golgi vesicle transport Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	5587	18760
Ensembl	ENSG00000184304	ENSMUSG00000002688
UniProt	Q15139	Q62101
RefSeq (mRNA)	NM_002742 NM_001330069 NM_001348390	NM_008858
RefSeq (protein)	NP_001316998 NP_002733 NP_001335319	NP_032884.2 NP_032884
Location (UCSC)	Chr 14: 29.58 – 30.19 Mb	Chr 12: 50.34 – 50.65 Mb
PubMed search

5587

18760

ENSG00000184304

ENSMUSG00000002688

Q15139

Q62101

NM_002742
NM_001330069
NM_001348390

NM_008858

NP_001316998
NP_002733
NP_001335319

NP_032884.2
NP_032884

Serine/threonine-protein kinase D1 is an enzyme that in humans is encoded by the PRKD1 gene.

Members of the protein kinase D (PKD) family function in many extracellular receptor-mediated signal transduction pathways. The PRKCM gene encodes a cytosolic serine-threonine kinase that binds to the trans-Golgi network and regulates the fission of transport carriers specifically destined to the cell surface.[supplied by OMIM]

Protein kinase D1 has been shown to interact with:

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Wikipedia