PRPF4B

PRPF4B
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4IAN, 4IFC, 4IIR, 4IJP
Identifiers
Aliases	PRPF4B, PR4H, PRP4, PRP4H, PRP4K, dJ1013A10.1, pre-mRNA processing factor 4B
External IDs	MGI: 109584 HomoloGene: 134085 GeneCards: PRPF4B
Gene ontology Molecular function • kinase activity • transferase activity • protein kinase activity • protein serine/threonine kinase activity • nucleotide binding • protein binding • ATP binding • cyclin-dependent protein serine/threonine kinase activity • RNA binding Cellular component • catalytic step 2 spliceosome • spliceosomal complex • nucleus • chromosome • nuclear speck Biological process • mRNA splicing, via spliceosome • protein phosphorylation • mRNA processing • RNA splicing • phosphorylation Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	8899	19134
Ensembl	ENSG00000112739	ENSMUSG00000021413
UniProt	Q13523	Q61136
RefSeq (mRNA)	NM_003913 NM_176800	NM_013830
RefSeq (protein)	NP_003904	NP_038858
Location (UCSC)	Chr 6: 4.02 – 4.06 Mb	Chr 13: 34.88 – 34.91 Mb
PubMed search

4IAN, 4IFC, 4IIR, 4IJP

8899

19134

ENSG00000112739

ENSMUSG00000021413

Q13523

Q61136

NM_003913
NM_176800

NM_013830

NP_003904

NP_038858

Serine/threonine-protein kinase PRP4 homolog is an enzyme that in humans is encoded by the PRPF4B gene.

Pre-mRNA splicing occurs in two sequential transesterification steps, and the protein encoded by this gene is thought to be involved in pre-mRNA splicing and in signal transduction. This protein belongs to a kinase family that includes serine/arginine-rich protein-specific kinases and cyclin-dependent kinases (CDKs). This protein is regarded as a CDK-like kinase (Clk) with homology to mitogen-activated protein kinases (MAPKs).

PRPF4B has been shown to interact with Pinin.

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