PTCH2

PTCH2
Identifiers
Aliases	PTCH2, PTC2, patched 2
External IDs	MGI: 1095405 HomoloGene: 37842 GeneCards: PTCH2
Gene ontology Molecular function • hedgehog receptor activity • hedgehog family protein binding • smoothened binding Cellular component • membrane • integral component of membrane Biological process • skin development • positive regulation of epidermal cell differentiation • hair cycle • epidermal cell fate specification • cell fate determination • negative regulation of smoothened signaling pathway • epidermis development • signal transduction Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	8643	19207
Ensembl	ENSG00000117425	ENSMUSG00000028681
UniProt	Q9Y6C5	O35595
RefSeq (mRNA)	NM_003738 NM_001166292	NM_008958 NM_001312903
RefSeq (protein)	NP_001159764 NP_003729	NP_001299832 NP_032984
Location (UCSC)	Chr 1: 44.82 – 44.84 Mb	Chr 4: 117.1 – 117.12 Mb
PubMed search

8643

19207

ENSG00000117425

ENSMUSG00000028681

Q9Y6C5

O35595

NM_003738
NM_001166292

NM_008958
NM_001312903

NP_001159764
NP_003729

NP_001299832
NP_032984

Patched 2 is a protein that in humans is encoded by the PTCH2 gene.

This gene encodes a transmembrane receptor of the patched gene family. The encoded protein may function as a tumor suppressor in the hedgehog signaling pathway.

Alterations in this gene have been associated with nevoid basal cell carcinoma syndrome, basal cell carcinoma, medulloblastoma, and susceptibility to congenital macrostomia.

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