PTGES2

PTGES2
Identifiers
Aliases	PTGES2, C9orf15, GBF-1, GBF1, PGES2, mPGES-2, prostaglandin E synthase 2
External IDs	MGI: 1917592 HomoloGene: 11819 GeneCards: PTGES2
EC number	5.3.99.3
Gene ontology Molecular function • protein disulfide oxidoreductase activity • DNA binding • glutathione binding • isomerase activity • protein binding • heme binding • lyase activity • electron carrier activity • prostaglandin-E synthase activity Cellular component • cytoplasm • integral component of membrane • Golgi apparatus • membrane • Golgi membrane • mitochondrion • perinuclear region of cytoplasm • nucleus • extracellular region • cytosol • azurophil granule lumen Biological process • prostaglandin metabolic process • lipid metabolic process • cell redox homeostasis • fatty acid metabolic process • secretion • positive regulation of transcription, DNA-templated • fatty acid biosynthetic process • prostaglandin biosynthetic process • oxidation-reduction process • cyclooxygenase pathway • neutrophil degranulation Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	80142	96979
Ensembl	ENSG00000148334	ENSMUSG00000026820
UniProt	Q9H7Z7	Q8BWM0
RefSeq (mRNA)	NM_001256335 NM_025072 NM_198938 NM_198939 NM_198940	NM_133783
RefSeq (protein)	NP_001243264 NP_079348 NP_945176	NP_598544
Location (UCSC)	Chr 9: 128.12 – 128.13 Mb	Chr 2: 32.4 – 32.41 Mb
PubMed search

80142

96979

ENSG00000148334

ENSMUSG00000026820

Q9H7Z7

Q8BWM0

NM_001256335
NM_025072
NM_198938
NM_198939
NM_198940

NM_133783

NP_001243264
NP_079348
NP_945176

NP_598544

Prostaglandin E synthase 2 is an enzyme that in humans encoded by the PTGES2 gene located on chromosome 9. The protein encoded by this gene is a membrane-associated prostaglandin E synthase, which catalyzes the conversion of prostaglandin H2 to prostaglandin E2. This protein also has been shown to activate the transcription regulated by a gamma-interferon-activated transcription element (GATE). Multiple transcript variants have been found for this gene.

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