PTPRD

PTPRD
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 1X5Z, 2DLH, 2YD6, 2YD7, 4RCA
Identifiers
Aliases	PTPRD, HPTP, HPTPD, HPTPDELTA, PTPD, RPTPDELTA, protein tyrosine phosphatase, receptor type D
External IDs	HomoloGene: 88669 GeneCards: PTPRD
Gene ontology Molecular function • transmembrane receptor protein tyrosine phosphatase activity • phosphoprotein phosphatase activity • protein tyrosine phosphatase activity • hydrolase activity • receptor binding • cell adhesion molecule binding • phosphatase activity • protein binding Cellular component • extracellular exosome • membrane • integral component of membrane • integral component of plasma membrane • plasma membrane Biological process • presynaptic membrane assembly • transmembrane receptor protein tyrosine phosphatase signaling pathway • neuron differentiation • positive regulation of dendrite morphogenesis • protein dephosphorylation • phosphate-containing compound metabolic process • heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules • dephosphorylation • peptidyl-tyrosine dephosphorylation • positive regulation of synapse assembly Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	5789	n/a
Ensembl	ENSG00000153707 ENSG00000282932	n/a
UniProt	P23468 Q3KPI9	n/a
RefSeq (mRNA)	NM_001040712 NM_001171025 NM_002839 NM_130391 NM_130392 NM_130393	n/a
RefSeq (protein)	NP_001035802 NP_001164496 NP_002830 NP_569075 NP_569076 NP_569077 NP_569077.2	n/a
Location (UCSC)	Chr 9: 8.31 – 10.61 Mb	n/a
PubMed search		n/a

1X5Z, 2DLH, 2YD6, 2YD7, 4RCA

5789

n/a

ENSG00000153707
ENSG00000282932

n/a

P23468
Q3KPI9

n/a

NM_130393

n/a

NP_569077
NP_569077.2

n/a

Receptor-type tyrosine-protein phosphatase delta is an enzyme that in humans is encoded by the PTPRD gene.

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular region, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, thus represents a receptor-type PTP. The extracellular region of this protein is composed of three Ig-like and eight fibronectin type III-like domains. Studies of the similar genes in chick and fly suggest the role of this PTP is in promoting neurite growth, and regulating neurons axon guidance. Multiple tissue specific alternatively spliced transcript variants of this gene have been reported.

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