PTPRF

PTPRF
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1LAR, 2DJU, 2EDX, 2EDY, 2YD5, 2YD8, 4N5U, 2DN7
Identifiers
Aliases	PTPRF, LAR, BNAH2, protein tyrosine phosphatase, receptor type F
External IDs	MGI: 102695 HomoloGene: 20623 GeneCards: PTPRF
Genetically Related Diseases
amyotrophic lateral sclerosis
Gene ontology Molecular function • chondroitin sulfate proteoglycan binding • heparin binding • phosphoprotein phosphatase activity • phosphatase activity • protein complex binding • protein tyrosine phosphatase activity • transmembrane receptor protein tyrosine phosphatase activity • hydrolase activity Cellular component • integral component of membrane • membrane • integral component of plasma membrane • neuronal cell body • neuron projection • extracellular exosome • plasma membrane Biological process • neuron projection regeneration • regulation of axon regeneration • negative regulation of receptor binding • regulation of neuron projection development • protein dephosphorylation • transmembrane receptor protein tyrosine phosphatase signaling pathway • cell adhesion • peptidyl-tyrosine dephosphorylation • cell migration • dephosphorylation Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	5792	19268
Ensembl	ENSG00000142949	ENSMUSG00000033295
UniProt	P10586	A2A8L5
RefSeq (mRNA)	NM_002840 NM_130440 NM_001329137 NM_001329138 NM_001329139 NM_001329140	NM_011213
RefSeq (protein)	NP_001316066 NP_001316067 NP_001316068 NP_001316069 NP_002831 NP_569707	NP_035343.2 NP_035343
Location (UCSC)	Chr 1: 43.53 – 43.62 Mb	Chr 4: 118.21 – 118.29 Mb
PubMed search

1LAR, 2DJU, 2EDX, 2EDY, 2YD5, 2YD8, 4N5U, 2DN7

5792

19268

ENSG00000142949

ENSMUSG00000033295

P10586

A2A8L5

NM_001329140

NM_011213

NP_569707

NP_035343.2
NP_035343

Receptor-type tyrosine-protein phosphatase F is an enzyme that in humans is encoded by the PTPRF gene.

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. The extracellular region contains three Ig-like domains, and nine non-Ig like domains similar to that of neural cell adhesion molecule. This PTP was shown to function in the regulation of epithelial cell–cell contacts at adherens junctions, as well as in the control of beta-catenin signaling. An increased expression level of this protein was found in the insulin-responsive tissue of obese, insulin-resistant individuals, and may contribute to the pathogenesis of insulin resistance. Two alternatively spliced transcript variants of this gene, which encode distinct proteins, have been reported.

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