PTPRH

PTPRH
Identifiers
Aliases	PTPRH, R-PTP-H, SAP1, protein tyrosine phosphatase, receptor type H
External IDs	MGI: 3026877 HomoloGene: 37693 GeneCards: PTPRH
Gene location (Human) Chr. Chromosome 19 (human) Band 19q13.42 Start 55,181,248 bp End 55,209,506 bp
Gene location (Mouse) Chr. Chromosome 7 (mouse) Band 7|7 A1 Start 4,548,612 bp End 4,604,041 bp
RNA expression pattern More reference expression data
Orthologs
Species	Human	Mouse
Entrez	5794	545902
Ensembl	ENSG00000080031	ENSMUSG00000035429
UniProt	n/a	E9Q0N2
RefSeq (mRNA)	NM_001161440 NM_002842	NM_207270
RefSeq (protein)	n/a	NP_997153
Location (UCSC)	Chr 19: 55.18 – 55.21 Mb	Chr 7: 4.55 – 4.6 Mb
PubMed search

5794

545902

ENSG00000080031

ENSMUSG00000035429

n/a

E9Q0N2

NM_001161440
NM_002842

NM_207270

n/a

NP_997153

Receptor-type tyrosine-protein phosphatase H is an enzyme that in humans is encoded by the PTPRH gene.

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and a single intracytoplasmic catalytic domain, and thus represents a receptor-type PTP. The extracellular region contains eight fibronectin type III-like repeats and multiple N-glycosylation sites. The gene was shown to be expressed primarily in brain and liver, and at a lower level in heart and stomach. It was also found to be expressed in several cancer cell lines, but not in the corresponding normal tissues.

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Wikipedia