PTPRJ

PTPRJ
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2CFV, 2DLE, 2NZ6
Identifiers
Aliases	PTPRJ, CD148, DEP1, HPTPeta, R-PTP-ETA, SCC1, protein tyrosine phosphatase, receptor type J
External IDs	MGI: 104574 HomoloGene: 2130 GeneCards: PTPRJ
Gene ontology Molecular function • beta-catenin binding • phosphoprotein phosphatase activity • gamma-catenin binding • phosphatase activity • delta-catenin binding • mitogen-activated protein kinase binding • platelet-derived growth factor receptor binding • protein binding • hydrolase activity • protein kinase binding • protein tyrosine phosphatase activity Cellular component • integral component of membrane • cell projection • membrane • cell-cell junction • plasma membrane • integral component of plasma membrane • ruffle membrane • cell surface • cell junction • immunological synapse • extracellular exosome • specific granule membrane Biological process • negative regulation of platelet-derived growth factor receptor signaling pathway • negative regulation of protein kinase B signaling • positive regulation of protein kinase B signaling • negative regulation of epidermal growth factor receptor signaling pathway • protein dephosphorylation • contact inhibition • negative regulation of T cell receptor signaling pathway • regulation of cell adhesion • negative regulation of cell migration • negative regulation of MAP kinase activity • negative regulation of cell growth • positive regulation of focal adhesion assembly • platelet-derived growth factor receptor signaling pathway • positive chemotaxis • peptidyl-tyrosine dephosphorylation • T cell receptor signaling pathway • negative regulation of cell proliferation • negative regulation of vascular permeability • positive regulation of cell adhesion • dephosphorylation • neutrophil degranulation Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	5795	19271
Ensembl	ENSG00000149177	ENSMUSG00000025314
UniProt	Q12913	Q64455
RefSeq (mRNA)	NM_001098503 NM_002843	NM_001135657 NM_008982
RefSeq (protein)	NP_001091973 NP_002834	NP_033008.3 NP_001129129 NP_033008
Location (UCSC)	Chr 11: 47.98 – 48.17 Mb	Chr 2: 90.43 – 90.58 Mb
PubMed search

2CFV, 2DLE, 2NZ6

5795

19271

ENSG00000149177

ENSMUSG00000025314

Q12913

Q64455

NM_001098503
NM_002843

NM_001135657
NM_008982

NP_001091973
NP_002834

NP_033008.3
NP_001129129
NP_033008

Receptor-type tyrosine-protein phosphatase eta is an enzyme that in humans is encoded by the PTPRJ gene.

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region containing five fibronectin type III repeats, a single transmembrane region, and a single intracytoplasmic catalytic domain, and thus represents a receptor-type PTP. This PTP is present in all hematopoietic lineages, and was shown to negatively regulate T cell receptor signaling possibly through interfering with the phosphorylation of Phospholipase C Gamma 1 (PLCG1) and Linker for Activation of T Cells (LAT). This PTP was also found to dephosphorylate PDGF beta receptor, and may be involved in UV-induced signal transduction.

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