PTPRO

PTPRO
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2G59, 2GJT
Identifiers
Aliases	PTPRO, GLEPP1, NPHS6, PTP-OC, PTP-U2, PTPROT, PTPU2, R-PTP-O, protein tyrosine phosphatase, receptor type O
External IDs	MGI: 1097152 HomoloGene: 21564 GeneCards: PTPRO
Gene ontology Molecular function • phosphoprotein phosphatase activity • protein homodimerization activity • phosphatase activity • Wnt-protein binding • protein binding • protein tyrosine phosphatase activity • transmembrane receptor protein tyrosine phosphatase activity • hydrolase activity • identical protein binding Cellular component • integral component of membrane • lateral plasma membrane • membrane • growth cone • plasma membrane • dendritic spine • integral component of plasma membrane • axon • apical plasma membrane • neuron projection • extracellular exosome • lamellipodium Biological process • negative regulation of cell-substrate adhesion • negative regulation of neuron projection development • monocyte chemotaxis • negative regulation of retinal ganglion cell axon guidance • regulation of glomerular filtration • slit diaphragm assembly • protein dephosphorylation • glomerulus development • axon guidance • cell morphogenesis • glomerular visceral epithelial cell differentiation • peptidyl-tyrosine dephosphorylation • negative regulation of glomerular filtration • negative regulation of canonical Wnt signaling pathway • lamellipodium assembly • dephosphorylation Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	5800	19277
Ensembl	ENSG00000151490	ENSMUSG00000030223
UniProt	Q16827	E9Q612
RefSeq (mRNA)	NM_002848 NM_030667 NM_030668 NM_030669 NM_030670 NM_030671	NM_001164401 NM_001164402 NM_001164403 NM_011216
RefSeq (protein)	NP_002839 NP_109592 NP_109593 NP_109594 NP_109595 NP_109596	NP_001157873 NP_001157874 NP_001157875 NP_035346
Location (UCSC)	Chr 12: 15.32 – 15.6 Mb	Chr 6: 137.25 – 137.46 Mb
PubMed search

2G59, 2GJT

5800

19277

ENSG00000151490

ENSMUSG00000030223

Q16827

E9Q612

NM_030671

NM_001164401
NM_001164402
NM_001164403
NM_011216

NP_109596

NP_001157873
NP_001157874
NP_001157875
NP_035346

Receptor-type tyrosine-protein phosphatase O is an enzyme that in humans is encoded by the PTPRO gene.

This gene encodes a receptor-type protein tyrosine phosphatase containing a single intracellular catalytic domain with a characteristic signature motif. The gene product, which has a transmembrane domain, is an integral membrane protein. Several alternatively spliced transcript variants, some of which encode different isoforms of the protein, have been described. These variants exhibit tissue-specific expression.

...
Wikipedia