PTPRT

PTPRT
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2OOQ
Identifiers
Aliases	PTPRT, RPTPrho, protein tyrosine phosphatase, receptor type T
External IDs	MGI: 1321152 HomoloGene: 56924 GeneCards: PTPRT
Gene ontology Molecular function • protein tyrosine phosphatase activity • phosphatase activity • beta-catenin binding • protein binding • phosphoprotein phosphatase activity • hydrolase activity • alpha-catenin binding • cadherin binding • delta-catenin binding • gamma-catenin binding Cellular component • integral component of membrane • cell surface • plasma membrane • membrane Biological process • protein dephosphorylation • cell adhesion • signal transduction • homophilic cell adhesion via plasma membrane adhesion molecules • transmembrane receptor protein tyrosine kinase signaling pathway • dephosphorylation • peptidyl-tyrosine dephosphorylation Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	11122	19281
Ensembl	ENSG00000196090	ENSMUSG00000053141
UniProt	O14522	Q99M80
RefSeq (mRNA)	NM_007050 NM_133170	NM_001291149 NM_001291150 NM_001291151 NM_021464
RefSeq (protein)	NP_008981 NP_573400	NP_001278078.1 NP_001278079.1 NP_067439.1 NP_001278078 NP_001278079 NP_001278080 NP_067439
Location (UCSC)	Chr 20: 42.07 – 43.19 Mb	Chr 2: 161.52 – 162.66 Mb
PubMed search

2OOQ

11122

19281

ENSG00000196090

ENSMUSG00000053141

O14522

Q99M80

NM_007050
NM_133170

NM_001291149
NM_001291150
NM_001291151
NM_021464

NP_008981
NP_573400

NP_001278080
NP_067439

Receptor-type tyrosine-protein phosphatase T is an enzyme that in humans is encoded by the PTPRT gene.

PTPRT is also known as PTPrho, PTPρ and human accelerated region 9. The human accelerated regions are 49 regions of the human genome that are conserved among vertebrates, but in humans show significant distinction from other vertebrates. This region may, therefore, have played a key role in differentiating humans from apes.

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