Parathyroid hormone-related protein

PTHLH
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3H3G, 1BZG, 1M5N, 3FFD
Identifiers
Aliases	PTHLH, BDE2, HHM, PLP, PTHR, PTHRP, parathyroid hormone-like hormone
External IDs	MGI: 97800 HomoloGene: 2113 GeneCards: PTHLH
Gene ontology Molecular function • peptide hormone receptor binding • hormone activity Cellular component • extracellular region • nucleus • Golgi apparatus • nucleoplasm • extracellular space • cytoplasm • cytosol Biological process • regulation of gene expression • positive regulation of cAMP biosynthetic process • skeletal system development • osteoblast development • cell-cell signaling • female pregnancy • regulation of chondrocyte differentiation • negative regulation of chondrocyte differentiation • adenylate cyclase-activating G-protein coupled receptor signaling pathway • cAMP metabolic process • positive regulation of cell proliferation • negative regulation of cell proliferation • epidermis development Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	5744	19227
Ensembl	ENSG00000087494	ENSMUSG00000048776
UniProt	P12272	P22858
RefSeq (mRNA)	NM_002820 NM_198964 NM_198965 NM_198966	NM_008970
RefSeq (protein)	NP_002811 NP_945315 NP_945316 NP_945317	n/a
Location (UCSC)	Chr 12: 27.96 – 27.97 Mb	Chr 6: 147.25 – 147.26 Mb
PubMed search

3H3G, 1BZG, 1M5N, 3FFD

5744

19227

ENSG00000087494

ENSMUSG00000048776

P12272

P22858

NM_002820
NM_198964
NM_198965
NM_198966

NM_008970

NP_002811
NP_945315
NP_945316
NP_945317

n/a

Parathyroid hormone-related protein (or PTHrP) is a protein member of the parathyroid hormone family. It is occasionally secreted by cancer cells (breast cancer, certain types of lung cancer including squamous cell lung carcinoma). However, it also has normal functions.

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