Phosphoglucose isomerase

Glucose-6-phosphate isomerase
Glucose-6-phosphate isomerase dimer, Rabbit
Identifiers
EC number	5.3.1.9
CAS number	9001-41-6
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / QuickGO
Search PMC articles PubMed articles NCBI proteins

Bacterial phosphoglucose isomerase C-terminal region
crystal structure of phosphoglucose/phosphomannose isomerase from pyrobaculum aerophilum in complex with fructose 6-phosphate
Identifiers
Symbol	bact-PGI_C
Pfam	PF10432
InterPro	IPR019490
CDD	cd05016
Available protein structures: Pfam structures PDB RCSB PDB; PDBe; PDBj PDBsum structure summary

GPI
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1NUH, 1IAT, 1IRI, 1JIQ, 1JLH
Identifiers
Aliases	GPI, AMF, GNPI, NLK, PGI, PHI, SA-36, SA36, glucose-6-phosphate isomerase
External IDs	OMIM: 172400 MGI: 95797 HomoloGene: 145 GeneCards: GPI
Gene location (Human) Chr. Chromosome 19 (human) Band 19q13.11 Start 34,359,480 bp End 34,402,156 bp
Gene location (Mouse) Chr. Chromosome 7 (mouse) Band 7 B1|7 19.46 cM Start 34,201,330 bp End 34,230,336 bp
Gene ontology Molecular function • cytokine activity • monosaccharide binding • intramolecular transferase activity • glucose-6-phosphate isomerase activity • isomerase activity • growth factor activity • ubiquitin protein ligase binding Cellular component • membrane • myelin • plasma membrane • nucleoplasm • ciliary membrane • neuron projection • extracellular exosome • extracellular region • extracellular space • cytoplasm • cytosol • secretory granule lumen • ficolin-1-rich granule lumen Biological process • negative regulation of neuron apoptotic process • hemostasis • gluconeogenesis • negative regulation of cysteine-type endopeptidase activity involved in apoptotic process • glycolytic process • glucose homeostasis • canonical glycolysis • mesoderm formation • aldehyde catabolic process • in utero embryonic development • erythrocyte homeostasis • humoral immune response • methylglyoxal biosynthetic process • angiogenesis • learning or memory • glucose 6-phosphate metabolic process • response to progesterone • response to morphine • response to immobilization stress • response to estradiol • response to testosterone • response to cadmium ion • response to muscle stretch • neutrophil degranulation • positive regulation of immunoglobulin secretion • carbohydrate metabolic process • regulation of receptor activity Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	2821	14751
Ensembl	ENSG00000282019 ENSG00000105220	ENSMUSG00000036427
UniProt	P06744	P06745
RefSeq (mRNA)	NM_000175 NM_001184722 NM_001289789 NM_001289790 NM_001329909 NM_001329910 NM_001329911	NM_008155
RefSeq (protein)	NP_000166 NP_001171651 NP_001276718 NP_001276719 NP_001316838 NP_001316839 NP_001316840	NP_032181
Location (UCSC)	Chr 19: 34.36 – 34.4 Mb	Chr 19: 34.2 – 34.23 Mb
PubMed search

1NUH, 1IAT, 1IRI, 1JIQ, 1JLH

2821

14751

ENSG00000282019
ENSG00000105220

ENSMUSG00000036427

P06744

P06745

NM_001329910
NM_001329911

NM_008155

NP_001316839
NP_001316840

NP_032181

Glucose-6-phosphate isomerase (GPI), alternatively known as phosphoglucose isomerase (PGI) or phosphohexose isomerase (PHI), is an enzyme that in humans is encoded by the GPI gene on chromosome 19. This gene encodes a member of the glucose phosphate isomerase protein family. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. In the cytoplasm, the gene product functions as a glycolytic enzyme (glucose-6-phosphate isomerase) that interconverts glucose-6-phosphate (G6P) and fructose-6-phosphate (F6P). Extracellularly, the encoded protein (also referred to as neuroleukin) functions as a neurotrophic factor that promotes survival of skeletal motor neurons and sensory neurons, and as a lymphokine that induces immunoglobulin secretion. The encoded protein is also referred to as autocrine motility factor (AMF) based on an additional function as a tumor-secreted cytokine and angiogenic factor. Defects in this gene are the cause of nonspherocytic hemolytic anemia, and a severe enzyme deficiency can be associated with hydrops fetalis, immediate neonatal death and neurological impairment. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]