Phospholamban

Phospholamban pentamer
Identifiers
Symbol	Phospholamban
Pfam	PF04272
InterPro	IPR005984
SCOP	1fjk
SUPERFAMILY	1fjk
TCDB	1.A.50
OPM superfamily	70
OPM protein	1zll
Available protein structures: Pfam structures PDB RCSB PDB; PDBe; PDBj PDBsum structure summary

Available protein structures:
Pfam	structures
PDB	RCSB PDB; PDBe; PDBj
PDBsum	structure summary

PLN
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 1PLP, 1ZLL, 2HYN
Identifiers
Aliases	PLN, CMD1P, CMH18, PLB, phospholamban
External IDs	OMIM: 172405 HomoloGene: 136758 GeneCards: PLN
Gene ontology Molecular function • enzyme inhibitor activity • ATPase binding • calcium channel regulator activity • protein binding • ATPase inhibitor activity • identical protein binding Cellular component • integral component of membrane • vesicle • endoplasmic reticulum membrane • membrane • mitochondrial membrane • sarcoplasmic reticulum • protein complex • endoplasmic reticulum • mitochondrion • sarcoplasmic reticulum membrane • perinuclear region of cytoplasm • calcium ion-transporting ATPase complex Biological process • Notch signaling pathway • regulation of ryanodine-sensitive calcium-release channel activity • negative regulation of calcium ion binding • regulation of cardiac conduction • regulation of calcium ion transport • negative regulation of catalytic activity • regulation of heart contraction • regulation of cytosolic calcium ion concentration • cardiac muscle tissue development • negative regulation of heart contraction • response to testosterone • regulation of the force of heart contraction • regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion • negative regulation of ATPase activity • regulation of calcium-transporting ATPase activity • regulation of calcium ion import • response to zinc ion • cellular calcium ion homeostasis • regulation of relaxation of cardiac muscle • negative regulation of calcium ion transmembrane transporter activity • blood circulation • negative regulation of heart rate • negative regulation of calcium ion import • response to insulin • regulation of cardiac muscle cell contraction • negative regulation of calcium-transporting ATPase activity • negative regulation of calcium ion transport • adrenergic receptor signaling pathway involved in heart process • regulation of cardiac muscle cell membrane potential • regulation of the force of heart contraction by cardiac conduction • regulation of relaxation of muscle • negative regulation of calcium ion import into sarcoplasmic reticulum • protein homooligomerization • regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum • relaxation of cardiac muscle • calcium ion transport Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	5350	n/a
Ensembl	ENSG00000198523	n/a
UniProt	P26678	n/a
RefSeq (mRNA)	NM_002667	n/a
RefSeq (protein)	NP_002658	n/a
Location (UCSC)	Chr 6: 118.55 – 118.56 Mb	n/a
PubMed search		n/a

1PLP, 1ZLL, 2HYN

5350

n/a

ENSG00000198523

n/a

P26678

n/a

NM_002667

n/a

NP_002658

n/a

Phospholamban, also known as PLN or PLB, is a protein that in humans is encoded by the PLN gene. Phospholamban is a 52-amino acid integral membrane protein that regulates the Ca²⁺ pump in cardiac muscle cells.

This protein is found as a pentamer and is a major substrate for the cAMP-dependent protein kinase (PKA) in cardiac muscle. The protein is an inhibitor of cardiac muscle sarcoplasmic reticulum Ca⁺⁺-ATPase (SERCA2) in the unphosphorylated state, but inhibition is relieved upon phosphorylation of the protein. The relief of inhibition on Ca⁺⁺-ATPase leads to faster Ca⁺⁺ uptake into the sarcoplasmic reticulum, thereby contributing to the lusitropic response elicited in heart by beta-agonists. The protein is a key regulator of cardiac diastolic function . Mutations in this gene are a cause of inherited human dilated cardiomyopathy with refractory congestive heart failure.

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